About our research
We are interested in the application of nonlinear dynamics, pattern formation, and stochastic processes, to problems in biology. Much of ourwork revolves around the application of these methods to understand the mechanisms that underlie cardiac arrhythmias. Recently, we have been working on some aspects of spreading in biological networks. We are also developing models for subcellular signaling relevant to the remodeling of the heart.
Past lab members
Gonzalo Hernandez-Hernandez (UC Davis, Biophysics))
Varderes Barsegyan (CSU Long Beach, Computer Science)
Sina Zareian (Claremont Graduate School, Mathematics)
D'Artagnan Greene (UC Irvine, Biochemistry)
Jon Spalding (UC Riverside, Physics)
Jesse Myers ( Infosys, Programmer))
General review articles of the field targeting a broad audience:
1. A nice article by Alain Karma and Robert Gilmour (Physics Today) on pattern formation in the heart.
2. Alain Karma has written a nice review article emphasizing the physicist's perspective.
3. Don Bers has written a nice review article on calcium cycling and arryhthmias.
1 Excellent article by Professor Francisco Bezanilla on the "Molecular Basis of Excitability". Excellent introduction, by an expert in the field, on how ion channels regulate the electrical potential across cells.
2. Elizabeth Cherry and Flavio Fenton at Cornell have put together a nice collections of Java applets on various aspects of excitable media and cardiac dynamics. Check out their website here.
3. Zhilin Qu has written a comprehensive review article on various theoretical approaches to calcium cycling.
4. Markus Bar and Blas Echebarria have written a comprehensive review article on excitable systems with an emphasis on the heart.
Past thesis from the group:
D'ary thesis: nucleation in cardiac tissue
Gonzalo thesis: fluctuations on networks