Rachel Mackelprang, Assistant Professor
Office: Eucalyptus Hall 2207
Lab: Eucalyptus Hall 2206
Paper mail: Department of Biology, California State University, 18111 Nordhoff St., Northridge, CA 91330-8303
Post Doctoral Fellow (2007 - 2011). Joint Genome Institute/Lawrence Berkeley National Laboratory
Ph.D. (2006). University of Washington. Department of Genome Sciences
B.S. (2001). University of Utah. Department of Biology
I am a genomicist focused on environmental metagenomics. Microbes are the engines that power fundamental biogeochemical cycles. Large-scale anthropogenic alterations in the environment are predicted to greatly affect microbial life, altering the balance of these cycles in the biosphere. While most microbes in the environment are recalcitrant to culturing, metagenomics provides access to the genomes of "inaccessible" organisms by isolating and sequencing all DNA from a particular environment. I am interested in leveraging ultra high-throughput sequencing, bioinformatic analysis, and microbiology-based approaches to study microbial community response to human-caused environmental perturbations and determine the impact of microbes on biogeochemical cycles. Current study systems include the thawing permafrost, the Gulf of Mexico Deepwater Horizon oil spill, and the great prairie of the Midwestern United States.
Mackelprang R, Waldrop MP, DeAngelis KM, Chavarria K, Blazewicz SJ, Rubin EM, Jansson JK. Deep metagenome sequencing illuminates permafrost response to thaw. Manuscript under review
Mason OU, Hazen TC, Borglin S, Chain P, Dubinsky EA, Fortney J, Han J, Holman
H-YN, Hultman J, Lamendella R, Mackelprang R, Tom LM, Tringe SG, Woyke T, Zhou J, Rubin EM, Jansson JK. Multo-omics analyses reveal a chemotactic response by dominant, aliphatic hydrocarbon degrading Bacteria to the Deepwater Horizon deep-sea plume. Manuscript under review
Graham DE, Wallenstein MD, Vishnivetskaya TA, Waldrop MP, Phelps TJ, Pfiffner SM, Onstott TC, Whyte LG, Rivkina E, Gilichinsky DA, Elis DA, Mackelprang R,VerBerkmoes NC, Hettich RL, Wagner DW, Wullschleger SD, Jansson JK. Microbes in the thawing permafrost: The unknown variable in the climate change equation. Manuscript under review
Gilbert JA, Meyer F, Antonopoulos D, Balaji P, Brown CT, Brown CT, Desai N,
Eisen JA, Evers D, Field D, Feng W, Huson D, Jansson J, Knight R, Knight J, Kolker
F, Konstantindis K, Kostka J, Kyrpides N, Mackelprang, R, HcHardy A, Quince C,
Raes J, Sczyrba A, Shade A, Stevens R. Meting report: the terabase metagenomics
workshop and the vision of an Earth microbiome project. Stand Genomic Sci 2010;
Mackelprang R, Rubin E. New tricks with old bones. Science 2008; 321:211-212
Mackelprang R, Livingston RJ, Eberle MA, Carlson CS, Yi Q, Akay JM, Nickerson DA. Sequence diversity, natural selection and linkage disequilibrium in the human T cell receptor alpha/delta locus. Hum Genet 2006; 119:255-266.
Yvert G, Brem RB, Whittle JW, Akey JM, Foss E, Smith EN, Mackelprang R, Kruglyak L. Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors. Nat Genet 2003; 35:57-64.
Mackelprang R, Carlson CS, Subrahmanyan L, Livingston RJ, Eberle MA, Nickerson DA. Sequence variation in the human T-cell receptor loci. Immunol Rev 2002; 190:26-39.
Mackelprang R, Dearing MD, St Jeor S. High prevalence of Sin Nombre virus in rodent populations, central Utah: a consequence of human disturbance? Emerg Infect Dis 2001; 7:480-482