Handouts To Print

Endocrine Function

MEF Highfield

Key Concepts

• Effects of each hormone may be classified

– HYPERsecretion or

– HYPOsecretion.

• HYPERsecretion effects are exaggerated normal actions of the hormones.

• HYPOsecretion effects are weakness/absence of normal actions of the hormones

HYPERsecretion Effects

• A gland either makes or releases too much hormone.

• A hormone is degraded too slowly.

• Another body site makes and secretes the hormone

HYPOsecretion Effects

• Secretory cells are unable to produce or obtain adequate hormone precursors.

• Secretory cells are unable to convert the precursors into the hormones.

• The hormone is degraded too fast.

• The hormone is inactivated by antibodies before reaching its target cell.

• The target cell fails to respond to its hormone because of:

Receptor absence or dysfunction or
Intracellular dysfunction caused by failure to form or respond to the "second messenger“

Reference:Parkinson, C. (1994). Study guide and workbook to accompany pathophysiology: The biologic basis for disease in adults and children (2nd ed.). Mosby: St. Louis. (Chapter 18 for all students).

Create a Table showing the effects of HYPER or HYPO secretion of each of the following

Handouts To Print

Endocrine Function

MEF Highfield

Key Concepts

• Effects of each hormone may be classified

– HYPERsecretion or

– HYPOsecretion.

• HYPERsecretion effects are exaggerated normal actions of the hormones.

• HYPOsecretion effects are weakness/absence of normal actions of the hormones

HYPERsecretion Effects

• A gland either makes or releases too much hormone.

• A hormone is degraded too slowly.

• Another body site makes and secretes the hormone

HYPOsecretion Effects

• Secretory cells are unable to produce or obtain adequate hormone precursors.

• Secretory cells are unable to convert the precursors into the hormones.

• The hormone is degraded too fast.

• The hormone is inactivated by antibodies before reaching its target cell.

• The target cell fails to respond to its hormone because of:

Receptor absence or dysfunction or

Intracellular dysfunction caused by failure to form or respond to the "second messenger“

Reference:Parkinson, C. (1994). Study guide and workbook to accompany pathophysiology: The biologic basis for disease in adults and children (2nd ed.). Mosby: St. Louis. (Chapter 18 for all students).

Create a Table showing the effects of HYPER or HYPO secretion of each of the following

• #1: ADH

• #2: Aldosterone

• #3: Thyroid hormones

• #4: Adrenal medulla hormones

• #5: Pancreatic Islet cells