California State University Northridge

Biology 470 - Biotechnology


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Dr. Stan Metzenberg
Department of Biology
California State University Northridge
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Class meetings: Thursdays from 6:00 PM until 9:00 PM, room Sc2225
Office hours: room Sc4100/4103, Thursdays from 11:00-12:00 AM
Telephone: 818-677-3335
Course home page:

Prerequisites: Biology 360 (Genetics) and Biology 380 (Cell Biology).
Required text: Bernard R. Glick & Jack J. Pasternak, Molecular Biotechnology, 3nd edition. ASM Press, Washington D.C., 2002.

Required exam form: Scantron form no. 882-ES


# Thursday Advance reading Subjects covered and midterm exam schedule
1 January 31 Chapt. 1-3 Review of the principles of molecular genetics.
2 February 7 Chapt. 4 Recombinant DNA Technology
3 February 14 Chapt. 5 DNA Synthesis, Sequencing, and Amplification
4 February 21 Chapt. 6-7 Manipulation of prokaryotic and eukaryotic gene expression
5 February 28 Chapt. 8 Directed mutagenesis and protein engineering
6 March 7 Chapt. 9 Review (chapters 1-8)

Molecular Diagnostics
7 March 14 Chapt. 10-11 Microbial production of therapeutic agents;Vaccines,
8 March 21 Exam - on line
9 April 4 Chapt. 14-15 Plant growth-promoting bacteria, microbial insecticides
10 April 11 Chapt. 16 Large-scale production of recombinant proteins
11 April 18 Chapt. 17 Genetic engineering of plants.
12 April 25 Chapt. 18 Guest speakers - DPC

Transgenic Plant Applications

Take-home exam is available (chapters 9-11, 14-16)
13 May 2 Chapt. 19 Transgenic animals

May 3: Take-home exam due on-line
14 May 9 Chapt. 20 Human molecular genetics.
15 May 16 Chapt. 21 Human gene therapy

Term paper due (1,500 words. Topic from Chapt. 17-21)

Final Exam (see below): Thursday, May 23, 20:00 - 22:00, room Sc2225

What's on the Biol 470 final exam?

Basis of final grade in course:

25% Class attendance, participation, and term paper
25% First midterm exam
25% Second midterm exam
25% Final exam

Course description: The application of organisms, biological systems, and processes to manufacturing and service industries. The role of microorganisms in industrial, agricultural, and pharmaceutical processes, biologically produced sources of energy, single cell protein, waste management, mining, and other areas. The impact of genetic engineering; enzyme biotechnology; recent advances in the genetics and physiology of industrial microorganisms for strain improvement. Lecture 3 hours.

Biology Department Withdrawal Policy: Unrestricted withdrawals are permitted only until the end of the third week. Thereafter, requests to drop a class will be honored only when a verifiable serious and compelling reason exists and when there is no viable alternative to withdrawal. Poor performance is not an acceptable reason for withdrawal. During the last three weeks of the semester withdrawals will not be approved except when a student is withdrawing from all classes for verifiable medical reasons.

Cheating and plagiarism: All forms of cheating and plagiarism (the claiming of the work of others as your own) are expressly forbidden by University rules and will not be tolerated. Any student observed cheating or participating in any act of academic dishonesty will have his or her case referred to the Office of the Vice President of Student Affairs for possible University disciplinary action. In addition, the student may receive a failing grade in the course.

Stan Metzenberg, Department of Biology, California State University Northridge, 18111 Nordhoff St., Northridge CA 91330-8303.