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Dr. Taeboem Oh |
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Long term objectives: |
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We propose the synthesis of a variety of ergot and histrionicotoxin alkaloids that have demonstrated activity in muscular, vascular, and central nervous systems, and nicotinic acetylcholine receptors |
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Importance: |
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The specific targets for the proposal period are elymolclavine, VUFB, perhydronicotoxin, and histrionicotoxin 235A. As many of the ergot alkaloids have multiplied pharmacological activities, our aim is to develop methods for efficient syntheses of these compounds and their analogs; this will allow for further structure activity studies and development of these compounds with more selective activities. The targets we propose have potential benefits in the treatment of CNS disorders such as Alzheimer's and Parkinson's disease. |
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Summary: |
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The general aim of the program is to develop efficient new synthetic technologies that will allow target molecules and their analogs to be produced in sufficient quantities for detailed pharmacological evaluations. The studies will include direct participation in collaborative SAR studies. |
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Report Writing: |
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Journal format |
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