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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------MNGTEGPNFYVPFSNKTGVVRSPFEAPQY-----YLAEPWQF SMLAAYMFLLIMLGFPINFLTLYVTVQHK-KL----------------------------------RTPLNY ILLNLAVADLFMVFGGFTTTLYTSLH-GYFVF---------------------------------------- ---------------------GPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVC----KPMS-------- ----------NFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYI-PEGMQCSCGIDYYTP----------- ------------------------------------------------------------------------ -----------------------------------------------------------------HEETNNE SFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQQQES--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------ATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIF TH-------------------------------------------QGSDFGPIFMTIPAFFAKTSAVYNPVI YIMMN-------KQFRNCMVTTLCCGKNPLGDDEASTTVSKTETSQVAPA---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >pdb|3PQR.A|RHOact/1-348 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------MNGTEGPNFYVPFSNKTGVVRSPFEAPQY-----YLAEPWQF SMLAAYMFLLIMLGFPINFLTLYVTVQHK-KL----------------------------------RTPLNY ILLNLAVADLFMVFGGFTTTLYTSLH-GYFVF---------------------------------------- ---------------------GPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVC----KPMS-------- ----------NFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYI-PEGMQCSCGIDYYTP----------- ------------------------------------------------------------------------ -----------------------------------------------------------------HEETNNE SFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQQQES--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------ATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIF TH-------------------------------------------QGSDFGPIFMTIPAFFAKTSAVYNPVI YIMMN-------KQFRNCMVTTLCCGKNPLGDDEASTTVSKTETSQVAPA---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >pdb|2VT4.B|Beta1AR/1-483 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------MGDGWLPPDCGPHNRSGGGGATAAPTGSRQVSA-----ELLSQQWE AGMSLLMALVVLLIVAGNVLVIAAIGSTQ-RL----------------------------------QTLTNL FITSLACADLVVGLLVVPFGATLVVR-GTWLW---------------------------------------- ---------------------GSFLCELWTSLDVLCVTASIETLCVIAIDRYLAIT----SPFRY------- ----------QSLMTRARAKVIICTVWAISALVSFLPIMMHWWRD-EDPQALKCYQDPGC------------ ------------------------------------------------------------------------ -----------------------------------------------------------------CDFVTNR AYAIASSIISFYIPLLIMIFVALRVYREAKEQIRKIDRC-EGRFYGSQEQPQPPPLPQHQPILGNGRASKRK TS---------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------RVMAMREHKALKTLGIIMGVFTLCWLPFFLVNIVNV FN--------------------------------------------RDLVPDWLFVAFNWLGYANSAMNPII YCRSP-------DFRKAFKRLLAFPRKADRRLHAGGQPAPLPGGFISTLGSPEHSPGGTWSDCNGGTRGGSE SSLEERHSKTSRSESKMEREKNILATTRFYCTFLGNGDKAVFCTVLRIVKLFEDATCTCPHTHKLKMKWRFK QHQA-------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------MGQPGNGSAFLLAPNGSHAPDHDVT-----QERDEVWV VGMGIVMSLIVLAIVFGNVLVITAIAKFE-RL----------------------------------QTVTNY FITSLACADLVMGLAVVPFGAAHILM-KMWTF---------------------------------------- ---------------------GNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAIT----SPFKY------- ----------QSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRA-THQEAINCYAEETC------------ ------------------------------------------------------------------------ -----------------------------------------------------------------CDFFTNQ AYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKS-EGRFHVQNLSQVEQDGRTGHGLRRS------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------SKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHV IQ--------------------------------------------DNLIRKEVYILLNWIGYVNSGFNPLI YCRSP-------DFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGH QGTVPSDNIDSQGRNCSTNDSLL------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >pdb|3SN6.R|Beta2ARact/1-413 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------MGQPGNGSAFLLAPNGSHAPDHDVT-----QERDEVWV VGMGIVMSLIVLAIVFGNVLVITAIAKFE-RL----------------------------------QTVTNY FITSLACADLVMGLAVVPFGAAHILT-KTWTF---------------------------------------- ---------------------GNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAIT----SPFKY------- ----------QSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRA-THQEAINCYAEETC------------ ------------------------------------------------------------------------ -----------------------------------------------------------------CDFFTNQ AYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKS-EGRFHVQNLSQVEQDGRTGHGLRRS------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------SKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHV IQ--------------------------------------------DNLIRKEVYILLNWIGYVNSGFNPLI YCRSP-------DFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGH QGTVPSDNIDSQGRNCSTNDSLL------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >pdb|3PBL.A|D3/1-400 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------MASLSQLSSHLNYTCGAENST-----GASQARPH AYYALSYCALILAIVFGNGLVCMAVLKER-AL----------------------------------QTTTNY LVVSLAVADLLVATLVMPWVVYLEVT-GGVWNF--------------------------------------- ---------------------SRICCDVFVTLDVMMCTASIWNLCAISIDRYTAVV----MPVHYQHG---- ----------TGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTG-DPT----------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------VCSISNP DFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILT-RQNSQCNSVRPGFPQQTLSPDPAHLELKRYYS ICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQP------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >pdb|3RZE.A|H1/1-487 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------MSLPNSSCLLEDKMCEGNK-----TTMASPQL MPLVVVLSTICLVTVGLNLLVLYAVRSER-KL----------------------------------HTVGNL YIVSLSVADLIVGAVVMPMNILYLLM-SKWSL---------------------------------------- ---------------------GRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQ----QPLRY------- ----------LKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQ-QTSVRREDKCE--------------- ------------------------------------------------------------------------ -----------------------------------------------------------------TDFYDVT WFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELI-NRSLPSFSEIKLRPENPKGDAKKPGKESPWEV LKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQL KTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVS 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >pdb|3UON.A|M2/1-466 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------MNNSTNSSNNSLALT-----SPYKTFEV VFIVLVAGSLSLVTIIGNILVMVSIKVNR-HL----------------------------------QTVNNY FLFSLACADLIIGVFSMNLYTLYTVI-GYWPL---------------------------------------- ---------------------GPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVT----KPLTY------- ----------PVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIV-GVRTVEDGECY--------------- ------------------------------------------------------------------------ -----------------------------------------------------------------IQFFSNA AVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKE-PVANQDPVSPSLVQGRIVKPNNNNMPSSDDGL EHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRI GTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKK------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >pdb|4MQS.A|M2act/1-466 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------MNNSTNSSNNSLALT-----SPYKTFEV VFIVLVAGSLSLVTIIGNILVMVSIKVNR-HL----------------------------------QTVNNY FLFSLACADLIIGVFSMNLYTLYTVI-GYWPL---------------------------------------- ---------------------GPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVT----KPLTY------- ----------PVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIV-GVRTVEDGECY--------------- ------------------------------------------------------------------------ -----------------------------------------------------------------IQFFSNA AVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKE-PVANQDPVSPSLVQGRIVKPNNNNMPSSDDGL EHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRI GTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKK------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >pdb|4DAJ.A|M3/1-589 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVTQLGSYNISQETGNFSSNDTSSDPL-----GGHTIWQV VFIAFLTGFLALVTIIGNILVIVAFKVNK-QL----------------------------------KTVNNY FLLSLACADLIIGVISMNLFTTYIIM-NRWAL---------------------------------------- ---------------------GNLACDLWLSIDYVASNASVMNLLVISFDRYFSIT----RPLTY------- ----------RAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFV-GKRTVPPGECF--------------- ------------------------------------------------------------------------ -----------------------------------------------------------------IQFLSEP TITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGL-QASGTEAEAENFVHPTGSSRSCSSYELQQQGV KRSSRRKYGRCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLP GHSSILNSTKLPSSDNLQVSNEDLGTVDVERNAHKLQAQKSMGDGDNCQKDFTKLPIQLESAVDTGKTSDTN 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >pdb|4IAR.A|5HT1B/1-390 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQ-----DSISLPWK VLLVMLLALITLATTLSNAFVIATVYRTR-KL----------------------------------HTPANY LIASLAVTDLLVSILVMPISTMYTVT-GRWTL---------------------------------------- ---------------------GQVVCDFWLSSDITCCTASIWHLCVIALDRYWAIT----DAVEY------- ----------SAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKA-EEEVSEC------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------VVNTDHI LYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPN-RTGKRLTRAQLITDSPGSTSSVTSINSRVPDV PSESGSPVYVNQVKVRVSDALLEKK----------------------------------------------- ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >pdb|4NC3.A|5HT2B/1-481 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQI-----VEEQGNKL HWAALLILMVIIPTIGGNTLVILAVSLEK-KL----------------------------------QYATNY FLMSLAVADLLVGLFVMPIALLTIMF-EAMWPL--------------------------------------- ---------------------PLVLCPAWLFLDVLFSTASIWHLCAISVDRYIAIK----KPIQA------- ----------NQYNSRATAFIKITVVWLISIGIAIPVPIKGIETD-VDNPNNITCV---------------- ------------------------------------------------------------------------ -----------------------------------------------------------------LTKERFG DFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNK-PPQRLTWLTVSTVFQRDETPCSSPEKVAMLDG SRKDKALPNSGDETLMRRTSTIGKKS---------------------------------------------- ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------MPIMGS SVYITVELAIAVLAILGNVLVCWAVWLNS-NL----------------------------------QNVTNY FVVSLAAADIAVGVLAIPFAITISTG-FCA------------------------------------------ ---------------------ACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIR----IPLRY------- ----------NGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCG-QPKEGKNHSQGCGEGQVACLF----- ------------------------------------------------------------------------ -----------------------------------------------------------------EDVVPMN YMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQ-PLPGERA------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------RSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTF FCP------------------------------------------DCSHAPLWLMYLAIVLSHTNSVVNPFI YAYRI-------REFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAP HPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------MPIMGS SVYITVELAIAVLAILGNVLVCWAVWLNS-NL----------------------------------QNVTNY FVVSLAAADIAVGVLAIPFAITISTG-FCA------------------------------------------ ---------------------ACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIR----IPLRY------- ----------NGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCG-QPKEGKNHSQGCGEGQVACLF----- ------------------------------------------------------------------------ -----------------------------------------------------------------EDVVPMN YMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQ-PLPGERA------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------RSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTF FCP------------------------------------------DCSHAPLWLMYLAIVLSHTNSVVNPFI YAYRI-------REFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAP HPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNI-----SADKENSI KLTSVVFILICCFIILENIFVLLTIWKTK-KF----------------------------------HRPMYY FIGNLALSDLLAGVAYTANLLLSGAT-TYKL----------------------------------------- ---------------------TPAQWFLREGSMFVALSASVFSLLAIAIERYITML----KMKL-------- ----------HNGSNNFRLFLLISACWVISLILGGLPIMGWNCIS-ALSSCS-------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------TVLPLYH KHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFR-KNISKA-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >pdb|4GRV.A|NTS1act/1-424 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---MHLNSSVPQGTPGEPDAQPFSGPQSEMEATFLALSLSNGSGNTSESDTAGPNSDLD-----VNTDIYSK VLVTAIYLALFVVGTVGNSVTLFTLARKK-SLQSL-------------------------------QSTVHY HLGSLALSDLLILLLAMPVELYNFIW-VHHPWAF-------------------------------------- ---------------------GDAGCRGYYFLRDACTYATALNVASLSVARYLAIC----HPFKA------- ----------KTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQN-RSADGTHPGGLVCTPI---------- ------------------------------------------------------------------------ -----------------------------------------------------------------VDTATVK VVIQVNTFMSFLFPMLVISILNTVIANKLTVMVHQAAEQ-GRVCTVGTHNGLEHSTFNMTIE---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------MEGISIYTSDNYTEEMGSGDYDSMKEPCFR-----EENANFNK IFLPTIYSIIFLTGIVGNGLVILVMGYQK-KL----------------------------------RSMTDK YRLHLSVADLLFVITLPFWAVDAVAN-WYF------------------------------------------ ---------------------GNFLCKAVHVIYTVNLYSSVWILAFISLDRYLAIV----HATNS------- ----------QRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSE-ADDRYICDRFY--------------- ------------------------------------------------------------------------ -----------------------------------------------------------------PNDLWVV VFQFQHIMVGLILPGIVILSCYCIIISKLSHSK--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------GHQKRKALKTTVILILAFFACWLPYYIGISIDS FIL-LEIIKQG---------------------------------CEFENTVHKWISITEALAFFHCCLNPIL YAFLG-------AKFKTSAQHALTSGRPLEVLFQLSKGKRGGHSSVSTESESSSFHSS-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >pdb|4MBS.A|CCR5/1-352 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------MDYQVSSPIYDINYYTSEPCQK-----INVKQIAA RLLPPLYSLVFIFGFVGNMLVILILINYK-RL----------------------------------KSMTDI YLLNLAISDLFFLLTVPFWAHYAAAQ-WDF------------------------------------------ ---------------------GNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVV----HAVFA------- ----------LKARTVTFGVVTSVITWVVAVFASLPNIIFTRSQK-EGLHYTCSSHFPYS------------ ------------------------------------------------------------------------ -----------------------------------------------------------------QYQFWKN FQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNE------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------KKRHRDVRLIFTIMIVYFLFWAPYNIVLLLNT FQE-FFGLNN----------------------------------CSSSNRLDQAMQVTETLGMTHCCINPII YAFVG-------EEFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >pdb|4DJH.A|KappaOR/1-380 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEP-----AHISPAIP VIITAVYSVVFVVGLVGNSLVMFVIIRYT-KM----------------------------------KTATNI YIFNLALADALVTTTMPFQSTVYLMN-SWPF----------------------------------------- ---------------------GDVLCKIVLSIDYYNMFTSIFTLTMMSVDRYIAVC----HPVKA------- ----------LDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKV-REDVDVIECSLQFPDD---------- ------------------------------------------------------------------------ -----------------------------------------------------------------DYSWWDL FMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSR--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------EKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEA LGS-----------------------------------------TSHSTAALSSYYFCIALGYTNSSLNPIL YAFLD-------ENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >pdb|4DKL.A|MuOR/1-398 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------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M DSSAGPGNISDCSDPLAPASCSPAPGSWLNLSHVDGNQSDPCGPNRTGLGGSHSLCPQT-----GSPSMVTA ITIMALYSIVCVVGLFGNFLVMYVIVRYT-KM----------------------------------KTATNI YIFNLALADALATSTLPFQSVNYLMG-TWPF----------------------------------------- ---------------------GNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVC----HPVKA------- ----------LDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKY-RQGSIDCTLTFSH------------- ------------------------------------------------------------------------ -----------------------------------------------------------------PTWYWEN LLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSK--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHG-----AFLPLGLK VTIVGLYLAVCVGGLLGNCLVMYVILRHT-KM----------------------------------KTATNI YIFNLALADTLVLLTLPFQGTDILLG-FWPF----------------------------------------- ---------------------GNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAIC----HPIRA------- ----------LDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQV-EDEEIECLVEIPT------------- ------------------------------------------------------------------------ -----------------------------------------------------------------PQDYWGP VFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGS---------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >pdb|4EJ4.A|DeltaOR/1-372 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------MELVPSARAELQSSPLVNLSDAFPSAFPSAGANASGSPGAR-----SASSLALA IAITALYSAVCAVGLLGNVLVMFGIVRYT-KL----------------------------------KTATNI YIFNLALADALATSTLPFQSAKYLME-TWPF----------------------------------------- ---------------------GELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVC----HPVKA------- ----------LDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQP-RDGAVVCMLQFPS------------- ------------------------------------------------------------------------ -----------------------------------------------------------------PSWYWDT VTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSK--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------EKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWT LVD-I---------------------------------------NRRDPLVVAALHLCIALGYANSSLNPVL YAFLD-------ENFKRCFRQLCRTPCGRQEPGSLRRPRQATTRERVTACTPSDGPGGGAAA---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >pdb|3VW7.A|PAR1/1-425 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------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------MGPRRLLLVAACFSLCGPLLSARTRARRPESKATN ATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASG-----YLTSSWLT LFVPSVYTGVFVVSLPLNIMAIVVFILKM-KV----------------------------------KKPAVV YMLHLATADVLFVSVLPFKISYYFSG-SDWQF---------------------------------------- ---------------------GSELCRFVTAAFYCNMYASILLMTVISIDRFLAVV----YPMQS------- ----------LSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQ-VPGLGITTCHDVLSET---------- ------------------------------------------------------------------------ -----------------------------------------------------------------LLEGYYA YYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVAN------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------RSKKSRALFLSAAVFCIFIICFGPTNVLLIAHY SFL-SH--------------------------------------TSTTEAAYFAYLLCVCVSSISCCIDPLI YYYAS-------SECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >pdb|4NTJ.A|P2Y12/1-342 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------MQAVDNLTSAPGNTSLC-----TRDYKITQ VLFPLLYTVLFFVGLITNGLAMRIFFQIR-S-----------------------------------KSNFII FLKNTVISDLLMILTFPFKILSDAKL-GTGPL---------------------------------------- ---------------------RTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTT----RPFKT------- ----------SNPKNLLGAKILSVVIWAFMFLLSLPNMILTNRQP-RDKNVKKCSFLKS------------- ------------------------------------------------------------------------ -----------------------------------------------------------------EFGLVWH EIVNYICQVIFWINFLIVIVCYTLITKELYRSYVRTRG---------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >pdb|4K5Y.B|CRF1/1-415 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCN ASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQE-ILNEEKKSKVHY HVAAIINYLGHCISLVALLVAFVLFLR---ARSIRC--------------------------------LRNI IHANLIAAFILRNATWFVVQLTMS---PEV------------------------------------------ ------------------HQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVL---TYSTD------- ---------------RLRAWMFICIGWGVPFPIIVAWAIGKLYY--DNEKCWAGKRPG-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ VYTDYIYQGPMALVLLINFIFLFNIVRILMTKLR------ASTT---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >pdb|4L6R.A|GLR/1-477 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------------------------------------------------------------------------ ------------------------------------------------------------------------ -----MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSC WPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGE-EIEVQKEVAKMY SSFQVMYTVGYSLSLGALLLALAILGG---LSKLHC--------------------------------TRNA IHANLFASFVLKASSVLVIDGLLR---TRYSQKIGDDLSVSTWL---------------------------- ------------------SDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGL---ATLPE------- ---------------RSFFSLYLGIGWGAPMLFVVPWAVVKCLF--ENVQCWTSNDN--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLR------ARQM---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------HHTDYKFRLAKSTLTLIPLLGVHEVVFAF------ ----VTDEHAQ------------------------------------GTLRSAKLFFDLFLSSFQGLLVAVL YCFLN-------KEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETP LAGGLPRLAESPF----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >pdb|4OR2.A|MGLU1/1-1194 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------MVGLLLFFFPAIFLEVSLLPRSPGRKV LLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNI TLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTKKPIAGVIGPGSSSVAIQV QNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDA FKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLI GSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLEN PNFKRICTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLIKSSF IGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGVVRSVCSEPCLKG QIKVIRKGEVSCCWICTACKENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSN------------- -IESIIAIAFSCLGILVTLFVTLIFVL---YRDTPVVKSSS-----------------------------RE LCYIILAGIFLGYVCPFTLI-------AKPT----------------------------------------- ----------------------TTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSK-KKICTRKPRFMS ---------------AWAQVIIASILISVQLTLVVTLIIM------EPPMPILSYPSIKEVYLICNTS---- ------------------------------------------------------------------------ ------------------------------------------------------------------------ NLGVVAPLGYNGLLIMSCTYYAFKT---------------RNVPANFN------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------EAKYIAFTMYTTCIIWLAFVPIYFG-- ----SNY----------------------------------------------KIITTCFAVSLSVTVALGC MFTPKMYIIIA-KPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKAGAGNANSNGKSVSWSEPGG GQVPKGQHMWHRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDTSTKTLYNVEEEEDAQPIRFSPPG SPSMVVHRRVPSAATTPPLPSHLTAEETPLFLAEPALPKGLPPPLQQQQQPPPQQKSLMDQLQGVVSNFSTA IPDFHAVLAGPGGPGNGLRSLYPPPPPPQHLQMLPLQLSTFGEELVSPPADDDDDSERFKLLQEYVYEHERE GNTEEDELEEEEEDLQAASKLTPDDSPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVSYASVILRDYK QSSSTL------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >pdb|4OO9.A|MGLU5/1-1212 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------MVLLLILSVLLLKE DVRGSAQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLL PNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQV QNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEA FKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLL 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---------------------------------------------EAKYIAFTMYTTCIIWLAFVPIYFG-- ----SNY----------------------------------------------KIITMCFSVSLSATVALGC MFVPKVYIILA-KPERNVRSAFTTSTVVRMHVGDGKSSSAASRSSSLVNLWKRRGSSGETLRYKDRRLAQHK SEIECFTPKGSMGNGGRATMSSSNGKSVTWAQNEKSSRGQHLWQRLSIHINKKENPNQTAVIKPFPKSTESR GLGAGAGAGGSAGGVGATGGAGCAGAGPGGPESPDAGPKALYDVAEAEEHFPAPARPRSPSPISTLSHRAGS ASRTDDDVPSLHSEPVARSSSSQGSLMEQISSVVTRFTANISELNSMMLSTAAPSPGVGAPLCSSYLIPKEI QLPTTMTTFAEIQPLPAIEVTGGAQPAAGAQAAGDAARESPAAGPEAAAAKPDLEELVALTPPSPFRDSVDS GSTTPNSPVSESALCIPSSPKYDTLIIRDYTQSSSSL----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >pdb|4N4W.A|SMO/1-787 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----------------------------------------------------ADLEDNWETLNDNLKVIEKA DNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAE QLKTTRNAYIQKYLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWP DFLRCTPDRFPEGCTNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFT---------EAEH QDMHSYIAAFGAVTGLCTLFTLATFVA---DWRNSNRY-------------------------------PAV ILFYVNACFFVGSIGWLAQF-------MDGARREIVCRADGTMRLGEPTSNET------------------- -----------------------LSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFK----ALGTTYQPLSGK ------------------TSYFHLLTWSLPFVLTVAILAV------AQVDGDSVSGICFVGYKN-------- ------------------------------------------------------------------------ -----------------------------------------------------------------------Y RYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSN-----HPGLLSEKAASKI------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------NETMLRLGIFGFLAFGFVLITFSCHFYDF F---NQAEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPS--------LLVEKINLFAMFGTGIAMSTW V-----------WTKATLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSH DGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAEISPELQKR LGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWGAGDSCRQGAWTLVSNPFCPE PSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLMDTELMDADSDF------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|O14718|OPSX_HUMAN/1-337 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------MLRNNLGNSSDSKNEDG-----SVFSQTEH NIVATYLIMAGMISIISNIIVLGIFIKYK-EL----------------------------------RTPTNA IIINLAVTDIGVSSIGYPMSAASDLY-GSWKF---------------------------------------- ---------------------GYAGCQVYAGLNIFFGMASIGLLTVVAVDRYLTIC----LPDV-------- ----------GRRMTTNTYIGLILGAWINGLFWALMPIIGWASYA-PDPTGATCTINWR------------- ------------------------------------------------------------------------ -----------------------------------------------------------------KNDRSFV SYTMTVIAINFIVPLTVMFYCYYHVTLSIKHHTTSDCTE-SL------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|O14804|TAAR5_HUMAN/1-337 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------MRAVFIQGAEEHPAAFCYQVNGSCPR-----TVHTLGIQ LVIYLACAAGMLIIVLGNVFVAFAVSYFK-AL----------------------------------HTPTNF LLLSLALADMFLGLLVLPLSTIRSVE-SCWFF---------------------------------------- ---------------------GDFLCRLHTYLDTLFCLTSIFHLCFISIDRHCAIC----DPLLY------- ----------PSKFTVRVALRYILAGWGVPAAYTSLFLYTDVVET-RLSQWLEEMPCVG------------- ------------------------------------------------------------------------ -----------------------------------------------------------------SCQLLLN KFWGWLNFPLFFVPCLIMISLYVKIFVVATRQAQQITTL-SKSL---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------AGAAKHERKAAKTLGIAVGIYLLCWLPFTIDTMVDS LL--------------------------------------------HFITPPLVFDIFIWFAYFNSACNPII YVFSY-------QWFRKALKLTLSQKVFSPQTRTVDLYQE-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------MGSLYSEYLNPNKVQEHYNYTKETL-----ETQETTSR QVASAFIVILCCAIVVENLLVLIAVARNS-KF----------------------------------HSAMYL FLGNLAASDLLAGVAFVANTLLSGSV-TLRL----------------------------------------- ---------------------TPVQWFAREGSAFITLSASVFSLLAIAIERHVAIA----KVKL-------- ----------YGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLG-HLEACS-------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------TVLPLYA KHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMA----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------APQTLALLKTVTIVLGVFIVCWLPAFSILLLDY ACP------------------------------------------VHSCPILYKAHYFFAVSTLNSLLNPVI YTWRS-------RDLRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTV V----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|O95977|S1PR4_HUMAN/1-384 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGR-----GGPEDGGL GALRGLSVAASCLVVLENLLVLAAITSHM-RS----------------------------------RRWVYY CLVNITLSDLLTGAAYLANVLLSGAR-TFRL----------------------------------------- ---------------------APAQWFLREGLLFTALAASTFSLLFTAGERFATMV----RPVAE------- ----------SGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLC-AFDRCS-------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------SLLPLYS KRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRP--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------AARRKARRLLKTVLMILLAFLVCWGPLFGLLLADV FGS-----------------------------------------NLWAQEYLRGMDWILALAVLNSAVNPII YSFRS-------REVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDSFRGSRSLSFRM REPLSSISSVRSI----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------MRKMSEEEFYLFKNISSVGPWDGPQY-----HIAPVWAF YLQAAFMGTVFLIGFPLNAMVLVATLRYK-KL----------------------------------RQPLNY ILVNVSFGGFLLCIFSVFPVFVASCN-GYFVF---------------------------------------- ---------------------GRHVCALEGFLGTVAGLVTGWSLAFLAFERYIVIC----KPFG-------- ----------NFRFSSKHALTVVLATWTIGIGVSIPPFFGWSRFI-PEGLQCSCGPDWYTV----------- ------------------------------------------------------------------------ -----------------------------------------------------------------GTKYRSE SYTWFLFIFCFIVPLSLICFSYTQLLRALKAVAAQQQES--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------ATTQKAEREVSRMVVVMVGSFCVCYVPYAAFAMYMV NN-------------------------------------------RNHGLDLRLVTIPSFFSKSACIYNPII YCFMN-------KQFQACIMKMVCGKAMTDESDTCSSQKTEVSTVSSTQVGPN------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P04000|OPSR_HUMAN/1-364 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------MAQQWSLQRLAGRHPQDSYEDSTQSSIFTYTNSNSTRGPFEGPNY-----HIAPRWVY HLTSVWMIFVVTASVFTNGLVLAATMKFK-KL----------------------------------RHPLNW ILVNLAVADLAETVIASTISIVNQVS-GYFVL---------------------------------------- ---------------------GHPMCVLEGYTVSLCGITGLWSLAIISWERWLVVC----KPFG-------- ----------NVRFDAKLAIVGIAFSWIWSAVWTAPPIFGWSRYW-PHGLKTSCGPDVFSG----------- ------------------------------------------------------------------------ -----------------------------------------------------------------SSYPGVQ SYMIVLMVTCCIIPLAIIMLCYLQVWLAIRAVAKQQKES--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------ESTQKAEKEVTRMVVVMIFAYCVCWGPYTFFACFAA AN-------------------------------------------PGYAFHPLMAALPAYFAKSATIYNPVI YVFMN-------RQFRNCILQLFGKKVDDGSELSSASKTEVSSVSSVSPA---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P04001|OPSG_HUMAN/1-364 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------MAQQWSLQRLAGRHPQDSYEDSTQSSIFTYTNSNSTRGPFEGPNY-----HIAPRWVY HLTSVWMIFVVIASVFTNGLVLAATMKFK-KL----------------------------------RHPLNW ILVNLAVADLAETVIASTISVVNQVY-GYFVL---------------------------------------- ---------------------GHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVC----KPFG-------- ----------NVRFDAKLAIVGIAFSWIWAAVWTAPPIFGWSRYW-PHGLKTSCGPDVFSG----------- ------------------------------------------------------------------------ -----------------------------------------------------------------SSYPGVQ SYMIVLMVTCCITPLSIIVLCYLQVWLAIRAVAKQQKES--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------ESTQKAEKEVTRMVVVMVLAFCFCWGPYAFFACFAA AN-------------------------------------------PGYPFHPLMAALPAFFAKSATIYNPVI YVFMN-------RQFRNCILQLFGKKVDDGSELSSASKTEVSSVSSVSPA---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P07550|ADRB2_HUMAN/1-413 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------MGQPGNGSAFLLAPNGSHAPDHDVT-----QERDEVWV VGMGIVMSLIVLAIVFGNVLVITAIAKFE-RL----------------------------------QTVTNY FITSLACADLVMGLAVVPFGAAHILM-KMWTF---------------------------------------- ---------------------GNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAIT----SPFKY------- ----------QSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRA-THQEAINCYANETC------------ ------------------------------------------------------------------------ -----------------------------------------------------------------CDFFTNQ AYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKS-EGRFHVQNLSQVEQDGRTGHGLRRS------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------SKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHV IQ--------------------------------------------DNLIRKEVYILLNWIGYVNSGFNPLI YCRSP-------DFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGH QGTVPSDNIDSQGRNCSTNDSLL------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P08100|OPSD_HUMAN/1-348 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------MNGTEGPNFYVPFSNATGVVRSPFEYPQY-----YLAEPWQF SMLAAYMFLLIVLGFPINFLTLYVTVQHK-KL----------------------------------RTPLNY ILLNLAVADLFMVLGGFTSTLYTSLH-GYFVF---------------------------------------- ---------------------GPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVC----KPMS-------- ----------NFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYI-PEGLQCSCGIDYYTL----------- ------------------------------------------------------------------------ -----------------------------------------------------------------KPEVNNE SFVIYMFVVHFTIPMIIIFFCYGQLVFTVKEAAAQQQES--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------ATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIF TH-------------------------------------------QGSNFGPIFMTIPAFFAKSAAIYNPVI YIMMN-------KQFRNCMLTTICCGKNPLGDDEASATVSKTETSQVAPA---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P08172|ACM2_HUMAN/1-466 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------MNNSTNSSNNSLALT-----SPYKTFEV VFIVLVAGSLSLVTIIGNILVMVSIKVNR-HL----------------------------------QTVNNY FLFSLACADLIIGVFSMNLYTLYTVI-GYWPL---------------------------------------- ---------------------GPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVT----KPLTY------- ----------PVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIV-GVRTVEDGECY--------------- ------------------------------------------------------------------------ -----------------------------------------------------------------IQFFSNA AVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKE-PVANQDPVSPSLVQGRIVKPNNNNMPSSDDGL EHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRI GTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKK------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P08173|ACM4_HUMAN/1-479 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------MANFTPVNGSSGNQSVRLVTSSSH-----NRYETVEM VFIATVTGSLSLVTVVGNILVMLSIKVNR-QL----------------------------------QTVNNY FLFSLACADLIIGAFSMNLYTVYIIK-GYWPL---------------------------------------- ---------------------GAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVT----KPLTY------- ----------PARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVV-GKRTVPDNQCF--------------- ------------------------------------------------------------------------ -----------------------------------------------------------------IQFLSNP AVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPE-GPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAR EELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPA SRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKK-------------------- ------------------------------------RQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNT FC--------------------------------------------QSCIPDTVWSIGYWLCYVNSTINPAC YALCN-------ATFKKTFRHLLLCQYRNIGTAR-------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P08588|ADRB1_HUMAN/1-477 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESP-----EPLSQQWT AGMGLLMALIVLLIVAGNVLVIVAIAKTP-RL----------------------------------QTLTNL FIMSLASADLVMGLLVVPFGATIVVW-GRWEY---------------------------------------- ---------------------GSFFCELWTSVDVLCVTASIETLCVIALDRYLAIT----SPFRY------- ----------QSLLTRARARGLVCTVWAISALVSFLPILMHWWRA-ESDEARRCYNDPKC------------ ------------------------------------------------------------------------ -----------------------------------------------------------------CDFVTNR AYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSC-ERRFLGGPARPPSPSPSPVPAPAPPPGPPRPA AAAATAPLANGRAGKRRPS----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------RLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKA FH--------------------------------------------RELVPDRLFVFFNWLGYANSAFNPII YCRSP-------DFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPP ARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P08908|5HT1A_HUMAN/1-422 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------MDVLSPGQGNNTTSPPAPFETGGNTTGI-----SDVTVSYQ VITSLLLGTLIFCAVLGNACVVAAIALER-SL----------------------------------QNVANY LIGSLAVTDLMVSVLVLPMAALYQVL-NKWTL---------------------------------------- ---------------------GQVTCDLFIALDVLCCTSSILHLCAIALDRYWAIT----DPIDY------- ----------VNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPE-DRSDPDA------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------CTISKDH GYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKK-VEKTGADTRHGASPAPQPKKSVNGESGSRNWR LGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKR--- ------------------------------------------------------------------------ ------------------------------------KMALARERKTVKTLGIIMGTFILCWLPFFIVALVLP FCE------------------------------------------SSCHMPTLLGAIINWLGYSNSLLNPVI YAYFN-------KDFQNAFKKIIKCKFCRQ------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P08912|ACM5_HUMAN/1-532 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------MEGDSYHNATTVNGTPVNHQPL-----ERHRLWEV ITIAAVTAVVSLITIVGNVLVMISFKVNS-QL----------------------------------KTVNNY YLLSLACADLIIGIFSMNLYTTYILM-GRWAL---------------------------------------- ---------------------GSLACDLWLALDYVASNASVMNLLVISFDRYFSIT----RPLTY------- ----------RAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLV-GKRTVPLDECQ--------------- ------------------------------------------------------------------------ -----------------------------------------------------------------IQFLSEP TITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADL-QGSDSVTKAEKRKPAHRALFRSCLRCPRPTLA QRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPG EEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCP FPVAKEPSTKGLNPNPSHQMTKRK------------RVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVST FC--------------------------------------------DKCVPVTLWHLGYWLCYVNSTVNPIC YALCN-------RTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P08913|ADA2A_HUMAN/1-450 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------MGSLQPDAGNASWNGTEAPGGGARA-----TPYSLQVT LTLVCLAGLLMLLTVFGNVLVIIAVFTSR-AL----------------------------------KAPQNL FLVSLASADILVATLVIPFSLANEVM-GYWYF---------------------------------------- ---------------------GKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSIT----QAIEY------- ----------NLKRTPRRIKAIIITVWVISAVISFPPLISIEKKG-GGGGPQPAEPR--------------- ------------------------------------------------------------------------ -----------------------------------------------------------------CEINDQK WYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSR-RGPDAVAAPPGGTERRPNGLGPERSAGPGGAE AEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGP GATGIGTPAAGPGEERVGAAKASRW----------------------------------------------- ------------------------------------RGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTA V---------------------------------------------GCSVPRTLFKFFFWFGYCNSSLNPVI YTIFN-------HDFRRAFKKILCRGDRKRIV---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P11229|ACM1_HUMAN/1-460 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------MNTSAPPAVSPNITVLA-----PGKGPWQV AFIGITTGLLSLATVTGNLLVLISFKVNT-EL----------------------------------KTVNNY FLLSLACADLIIGTFSMNLYTTYLLM-GHWAL---------------------------------------- ---------------------GTLACDLWLALDYVASNASVMNLLLISFDRYFSVT----RPLSY------- ----------RAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLV-GERTVLAGQCY--------------- ------------------------------------------------------------------------ -----------------------------------------------------------------IQFLSQP IITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAAL-QGSETPGKGGGSSSSSERSQPGAEGSPETPPG RCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRP TKKGRDRAGKGQKPRGKEQLAKRK------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P13945|ADRB3_HUMAN/1-408 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------MAPWPHENSSLAPWPDLPTLAPNTANTSG-----LPGVPWEA ALAGALLALAVLATVGGNLLVIVAIAWTP-RL----------------------------------QTMTNV FVTSLAAADLVMGLLVVPPAATLALT-GHWPL---------------------------------------- ---------------------GATGCELWTSVDVLCVTASIETLCALAVDRYLAVT----NPLRY------- ----------GALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV-GADAEAQRCHSNPRC----------- ------------------------------------------------------------------------ -----------------------------------------------------------------CAFASNM PYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGE-LGRFPPEESPPAPSRSLAPAPVGTCAPPEGVP ACGRRPA----------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------RLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRA LG-------------------------------------------GPSLVPGPAFLALNWLGYANSAFNPLI YCRSP-------DFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS-- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P14416|DRD2_HUMAN/1-443 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------MDPLNLSWYDDDLERQNWSRPFNGSD-----GKADRPHY NYYATLLTLLIAVIVFGNVLVCMAVSREK-AL----------------------------------QTTTNY LIVSLAVADLLVATLVMPWVVYLEVV-GEWKF---------------------------------------- ---------------------SRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVA----MPMLYN------ ----------TRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNAD-QN------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------ECIIANP AFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTK-RSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMK SNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGH AKDHPKIAKIFEIQTMPNGKTRTSLKTMSRR----------------------------------------- ------------------------------------KLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNI HC--------------------------------------------DCNIPPVLYSAFTWLGYVNSAVNPII YTTFN-------IEFRKAFLKILHC----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P18089|ADA2B_HUMAN/1-447 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------MDHQ-----DPYSVQAT AAIAAAITFLILFTIFGNALVILAVLTSR-SL----------------------------------RAPQNL FLVSLAAADILVATLIIPFSLANELL-GYWYF---------------------------------------- ---------------------RRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVS----RALEY------- ----------NSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQG-PQPRGRPQ------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------CKLNQEA WYILASSIGSFFAPCLIMILVYLRIYLIAKRSNRRGPRA-KGGPGQGESKQPRPDHGGALASAKLPALASVA SAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEEEEEEEECEPQAVP VSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRR----------------------------- ------------------------------------RAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGA ICP------------------------------------------KHCKVPHGLFQFFFWIGYCNSSLNPVI YTIFN-------QDFRRAFRRILCRPWTQTAW---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P18825|ADA2C_HUMAN/1-462 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPR-----GQYSAGAV AGLAAVVGFLIVFTVVGNVLVVIAVLTSR-AL----------------------------------RAPQNL FLVSLASADILVATLVMPFSLANELM-AYWYF---------------------------------------- ---------------------GQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVT----QAVEY------- ----------NLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQP-DGAAYPQ------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------CGLNDET WYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEK-RAPVGPDGASPTTENGLGAAAGAGENGHCAPP PADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSR SVEFFLSRRRRARSSVCRR----------------------------------------------------- ------------------------------------KVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYG ICR------------------------------------------EACQVPGPLFKFFFWIGYCNSSLNPVI YTVFN-------QDFRRSFKHILFRRRRRGFRQ--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P20309|ACM3_HUMAN/1-590 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------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M TLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPL-----GGHTVWQV VFIAFLTGILALVTIIGNILVIVSFKVNK-QL----------------------------------KTVNNY FLLSLACADLIIGVISMNLFTTYIIM-NRWAL---------------------------------------- ---------------------GNLACDLWLAIDYVASNASVMNLLVISFDRYFSIT----RPLTY------- ----------RAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFV-GKRTVPPGECF--------------- ------------------------------------------------------------------------ -----------------------------------------------------------------IQFLSEP TITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGL-QASGTEAETENFVHPTGSSRSCSSYELQQQSM KRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLP GHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVN SSVGKSTATLPLSFKEATLAKRFALKTRSQITKRK-RMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNT FC--------------------------------------------DSCIPKTFWNLGYWLCYINSTVNPVC YALCN-------KTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P21453|S1PR1_HUMAN/1-382 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNI-----SADKENSI KLTSVVFILICCFIILENIFVLLTIWKTK-KF----------------------------------HRPMYY FIGNLALSDLLAGVAYTANLLLSGAT-TYKL----------------------------------------- ---------------------TPAQWFLREGSMFVALSASVFSLLAIAIERYITML----KMKL-------- ----------HNGSNNFRLFLLISACWVISLILGGLPIMGWNCIS-ALSSCS-------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------TVLPLYH KHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFR-KNISKA-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------SRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDV GCK------------------------------------------VKTCDILFRAEYFLVLAVLNSGTNPII YTLTN-------KEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSS GNVNSSS----------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P21554|CNR1_HUMAN/1-472 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKF PLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIEC-----FMVLNPSQ QLAIAVLSLTLGTFTVLENLLVLCVILHS-RSL---------------------------------RCRPSY HFIGSLAVADLLGSVIFVYSFIDFHV-FHRK----------------------------------------- ---------------------DSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISI----HRPLA------- ----------YKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCE-KLQSVC-------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------SDIFPHI DETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQ-RGTQKSIIIHTSEDGKVQVT------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------RPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYD VF-------------------------------------------GKMNKLIKTVFAFCSMLCLLNSTVNPI IYALR-------SKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVT MSVSTDTSAEAL------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P21728|DRD1_HUMAN/1-446 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------MRTLNTSAMDGTGLV-----VERDFSVR ILTACFLSLLILSTLLGNTLVCAAVIRFR-HLR---------------------------------SKVTNF FVISLAVSDLLVAVLVMPWKAVAEIA-GFWP----------------------------------------- ---------------------FGSFCNIWVAFDIMCSTASILNLCVISVDRYWAIS----SPFRY------- ----------ERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKA-KPTSPSDGNATSLAETIDN------- ------------------------------------------------------------------------ -----------------------------------------------------------------CDSSLSR TYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAAL-ERAAVHAKNCQTTTGNGKPVECSQPESSF--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------KMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILP FCG-SGE-------------------------------------TQPFCIDSNTFDVFVWFGWANSSLNPII YAFNA-------DFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAV GSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P21731|TA2R_HUMAN/1-343 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------MWPNGSSLGPCFRPTN-----ITLEERRL IASPWFAASFCVVGLASNLLALSVLAGAR-QGGSHT------------------------------RSSFLT FLCGLVLTDFLGLLVTGTIVVSQHAA-LFEWHAVDP------------------------------------ ---------------------GCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGIT----RPFSR------- ----------PAVASQRRAWATVGLVWAAALALGLLPLLGVGRYT-VQYPGSWCF----------------- ------------------------------------------------------------------------ -----------------------------------------------------------------LTLGAES GDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQE-AAQ----------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------QRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTV LRN-PPAMSPA---------------------------------GQLSRTTEKELLIYLRVATWNQILDPWV YILFR-------RAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ----------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P21917|DRD4_HUMAN/1-467 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------MGNRSTADADGLLAGRGPAAGASAGA-----SAGLAGQG AAALVGGVLLIGAVLAGNSLVCVSVATER-AL----------------------------------QTPTNS FIVSLAAADLLLALLVLPLFVYSEVQ-GGAWLL--------------------------------------- ---------------------SPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVA----VPLRY------- ----------NRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVR-GRDPA--------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------VCRLEDR DYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAK-LHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPD CAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGL PQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRR----------------------- ------------------------------------AKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQA LC-------------------------------------------PACSVPPRLVSAVTWLGYVNSALNPVI YTVFN-------AEFRNVFRKALRACC--------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P21918|DRD5_HUMAN/1-477 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAG-----APPLGPSQ VVTACLLTLLIIWTLLGNVLVCAAIVRSR-HLR---------------------------------ANMTNV FIVSLAVSDLFVALLVMPWKAVAEVA-GYWP----------------------------------------- ---------------------FGAFCDVWVAFDIMCSTASILNLCVISVDRYWAIS----RPFRY------- ----------KRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRD-QAASWGGLDLPNNLANWTPWEEDFWE PDVNAEN----------------------------------------------------------------- -----------------------------------------------------------------CDSSLNR TYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSL-ERAAEHAQSCRSSAACAPDTSL---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------RASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVP FCS-GHPEGPP---------------------------------AGFPCVSETTFDVFVWFGWANSSLNPVI YAFNA-------DFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNR EVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P25021|HRH2_HUMAN/1-359 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------MAPNGTASSF-----CLDSTACK ITITVVLAVLILITVAGNVVVCLAVGLNR-RL----------------------------------RNLTNC FIVSLAITDLLLGLLVLPFSAIYQLS-CKWSF---------------------------------------- ---------------------GKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVM----DPLRY------- ----------PVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSR-NETSKGNHTTSK-------------- ------------------------------------------------------------------------ -----------------------------------------------------------------CKVQVNE VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHI-SSW----------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------KAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRG LR-------------------------------------------GDDAINEVLEAIVLWLGYANSALNPIL YAALN-------RDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTA PQGATDR----------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P25100|ADA1D_HUMAN/1-572 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------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------MTFRDLLSVSFEGPRPDSSAGGSSAGGGG GSAGGAAPSEGPAVGGVPGGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVG-----GLVVSAQG VGVGVFLAAFILMAVAGNLLVILSVACNR-HL----------------------------------QTVTNY FIVNLAVADLLLSATVLPFSATMEVL-GFWAF---------------------------------------- ---------------------GRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVR----HSLKY------- ----------PAIMTERKAAAILALLWVVALVVSVGPLLGWKEPV-PPDERF-------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------CGITEEA GYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAG-VKRERGKASEVVLRIHCRGAATGADGAHGMRS AKGHTFRSSLSVR----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------LLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGS LF-------------------------------------------PQLKPSEGVFKVIFWLGYFNSCVNPLI YPCSS-------REFKRAFLRLLRCQCRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTA LPDPDPEPPGTPEMQAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSE VEAVSLGVPHEVAEGATCQAYELADYSNLRETDI-------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P28221|5HT1D_HUMAN/1-377 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------MSPLNQSAEGLPQEASNRSLNATETSEAWD-----PRTLQALK ISLAVVLSVITLATVLSNAFVLTTILLTR-KL----------------------------------HTPANY LIGSLATTDLLVSILVMPISIAYTIT-HTWNF---------------------------------------- ---------------------GQILCDIWLSSDITCCTASILHLCVIALDRYWAIT----DALEY------- ----------SKRRTAGHAATMIAIVWAISICISIPPLFWRQAKA-QEEMSDC------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------LVNTSQI SYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSL-YGKRFTTAHLITGSAGSSLCSLNSSLHEGHSH SAGSPLFFNHVKIKLADSALERK------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------RISAARERKATKILGIILGAFIICWLPFFVVSLVLP ICR------------------------------------------DSCWIHPALFDFFTWLGYLNSLINPII YTVFN-------EEFRQAFQKIVPFRKAS------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P28222|5HT1B_HUMAN/1-390 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQ-----DSISLPWK VLLVMLLALITLATTLSNAFVIATVYRTR-KL----------------------------------HTPANY LIASLAVTDLLVSILVMPISTMYTVT-GRWTL---------------------------------------- ---------------------GQVVCDFWLSSDITCCTASILHLCVIALDRYWAIT----DAVEY------- ----------SAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKA-EEEVSEC------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------VVNTDHI LYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPN-RTGKRLTRAQLITDSPGSTSSVTSINSRVPDV PSESGSPVYVNQVKVRVSDALLEKK----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------KLMAARERKATKTLGIILGAFIVCWLPFFIISLVMP ICK------------------------------------------DACWFHLAIFDFFTWLGYLNSLINPII YTMSN-------EDFKQAFHKLIRFKCTS------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P28223|5HT2A_HUMAN/1-471 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------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------MDILCEE NTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCL-----SLLHLQEK NWSALLTAVVIILTIAGNILVIMAVSLEK-KL----------------------------------QNATNY FLMSLAIADMLLGFLVMPVSMLTILY-GYRWPL--------------------------------------- ---------------------PSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQ----NPIHH------- ----------SRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDD-SKVFKEG------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------SCLLADD NFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSD-LGTRAKLASFSFLPQSSLSSEKLFQRSIHREP GSYTGRRT---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------MQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAV ICK-E---------------------------------------SCNEDVIGALLNVFVWIGYLSSAVNPLV YTLFN-------KTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCS MVALGKQHSEEASKDNSDGVNEKVSCV--------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P28335|5HT2C_HUMAN/1-458 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGR-----FKFPDGVQ NWPALSIVIIIIMTIGGNILVIMAVSMEK-KL----------------------------------HNATNY FLMSLAIADMLVGLLVMPLSLLAILY-DYVWPL--------------------------------------- ---------------------PRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIR----NPIEH------- ----------SRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDE-EKVFVNNT------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------TCVLNDP NFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHG-HTEEPPGLSLDFLKCCKRNTAEEENSANPNQD QNARRRKKKERRPRGT-------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------MQAINNERKASKVLGIVFFVFLIMWCPFFITNILSV LCE-K---------------------------------------SCNQKLMEKLLNVFVWIGYVCSGINPLV YTLFN-------KIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEP GIEMQVENLELPVNPSSVVSERISSV---------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------MPIMGS SVYITVELAIAVLAILGNVLVCWAVWLNS-NL----------------------------------QNVTNY FVVSLAAADIAVGVLAIPFAITISTG-FCA------------------------------------------ ---------------------ACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIR----IPLRY------- ----------NGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCG-QPKEGKNHSQGCGEGQVACLF----- ------------------------------------------------------------------------ -----------------------------------------------------------------EDVVPMN YMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQ-PLPGERA------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------MLLETQD ALYVALELVIAALSVAGNVLVCAAVGTAN-TL----------------------------------QTPTNY FLVSLAAADVAVGLFAIPFAITISLG-FCT------------------------------------------ ---------------------DFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAIC----VPLRY------- ----------KSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKD-SATNNCTEPWDGTTNESCCLVKCLF- ------------------------------------------------------------------------ -----------------------------------------------------------------ENVVPMS YMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELM-DHS----------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQI-----VEEQGNKL HWAALLILMVIIPTIGGNTLVILAVSLEK-KL----------------------------------QYATNY FLMSLAVADLLVGLFVMPIALLTIMF-EAMWPL--------------------------------------- ---------------------PLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIK----KPIQA------- ----------NQYNSRATAFIKITVVWLISIGIAIPVPIKGIETD-VDNPNNITCV---------------- ------------------------------------------------------------------------ -----------------------------------------------------------------LTKERFG DFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNK-PPQRLTWLTVSTVFQRDETPCSSPEKVAMLDG SRKDKALPNSGDETLMRRTSTIGKKS---------------------------------------------- ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------MNASCCLPSVQPTLPNGSEHLQAPFFSNQS-----SSAFCEQV FIKPEVFLSLGIVSLLENILVILAVVRNG-NL----------------------------------HSPMYF FLCSLAVADMLVSVSNALETIMIAIV-HSDYLTFEDQF---------------------------------- ---------------------IQHMDNIFDSMICISLVASICNLLAIAVDRYVTIF----YALRY------- ----------HSIMTVRKALTLIVAIWVCCGVCGVVFIVY-------------------------------- ------------------------------------------------------------------------ ---------------------------------------------------------------------SES KMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAAL-PPADGV-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------MSMNNSKQLVSPAAALLS-----NTTCQTEN RLSVFFSVIFMTVGILSNSLAIAILMKAY-QRFRQKS-----------------------------KASFLL LASGLVITDFFGHLINGAIAVFVYAS-DKEWIRFDQ------------------------------------ ---------------------SNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVT----KPIFH------- ----------STKITSKHVKMMLSGVCLFAVFIALLPILGHRDYK-IQASRTWCFYN--------------- ------------------------------------------------------------------------ -----------------------------------------------------------------TEDIKDW EDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQ-QH------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRP-----PGSGEDCG SVSVAFPITMLLTGFVGNALAMLLVSRSY-RRRESKR-----------------------------KKSFLL CIGWLALTDLVGQLLTTPVVIVVYLS-KQRWEHIDP------------------------------------ ---------------------SGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIR----APHWY------- ----------ASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYT-VQWPGTWCFISTGRGGNG-------- ------------------------------------------------------------------------ -----------------------------------------------------------------TSSSHNW GNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKA-TASQSS-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------MGNASNDSQSEDC-----ETRQWLPP GESPAISSVMFSAGVLGNLIALALLARRW-RGDVGCSAGRRSS-----------------------LSLFHV LVTELVFTDLLGTCLISPVVLASYAR-NQTLVALAP------------------------------------ ---------------------ESRACTYFAFAMTFFSLATMLMLFAMALERYLSIG----HPYFY------- ----------QRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYV-QYCPG--------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------TWCFIRH GRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSR-RSRCGPSLGSGRGGPGARRRGE---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------MADSC-----RNLTYVRG SVGPATSTLMFVAGVVGNGLALGILSARR-PAR---------------------------------PSAFAV LVTGLAATDLLGTSFLSPAVFVAYAR-NSSLLGLARG----------------------------------- ---------------------GPALCDAFAFAMTFFGLASMLILFAMAVERCLALS----HPYLY------- ----------AQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQ-QYCPGSWCFL---------------- ------------------------------------------------------------------------ -----------------------------------------------------------------RMRWAQP GGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQK-RHQGSLGPR----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------MMWGAGSPLAWLSAGSGNVNVSSVGPAEGPTG-----PAAPLPSP KAWDVVLCISGTLVSCENALVVAIIVGTP-AF----------------------------------RAPMFL LVGSLAVADLLAGLGLVLHFAAVFCI-G-------------------------------------------- ---------------------SAEMSLVLVGVLAMAFTASIGSLLAITVDRYLSLY----NALTY------- ----------YSETTVTRTYVMLALVWGGALGLGLLPVLAWNCLD-GLTTC--------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------GVVYPLS KNHLVVLAIAFFMVFGIMLQLYAQICRIVCRHAQQIALQ-RHLLP--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P46095|GPR6_HUMAN/1-362 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------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------MNAS AASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAG-----PPGLLLPA VNPWDVLLCVSGTVIAGENALVVALIAST-PA----------------------------------LRTPMF VLVGSLATADLLAGCGLILHFVFQYL-V-------------------------------------------- ---------------------PSETVSLLTVGFLVASFAASVSSLLAITVDRYLSL----YNALT------- ----------YYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCL-AERAA--------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------CSVVRPL ARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIAL-QQHCL--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P47775|GPR12_HUMAN/1-334 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------MNEDLKVNLSGLPRDYLDAAAAENISAAVSSRVPAV-----EPEPELVV NPWDIVLCTSGTLISCENAIVVLIIFHNP-SL----------------------------------RAPMFL LIGSLALADLLAGIGLITNFVFAYLL-Q-------------------------------------------- ---------------------SEATKLVTIGLIVASFSASVCSLLAITVDRYLSLY----YALTY------- ----------HSERTVTFTYVMLVMLWGTSICLGLLPVMGWNCLR-DESTC--------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------SVVRPLT KNNAAILSVSFLFMFALMLQLYIQICKIVMRHAHQIALQ-HHFLA--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPS-----SPLLSVFG VLILTLLGFLVAATFAWNLLVLATILRVR-TF----------------------------------HRVPHN LVASMAVSDVLVAALVMPLSLVHELS-GRRWQL--------------------------------------- ---------------------GRRLCQLWIACDVLCCTASIWNVTAIALDRYWSIT----RHMEY------- ----------TLRTRKCVSNVMIALTWALSAVISLAPLLFGWGET-YSEGSEE------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------CQVSREP SYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTN-SVSPISEAVEVKDSAKQPQMVFTVRHATVTFQ PEGD-------------------------------------------------------------------- ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P48039|MTR1A_HUMAN/1-350 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------MQGNGSALPNASQPVLRGD-----GARPSWLA SALACVLIFTIVVDILGNLLVILSVYRNK-KL----------------------------------RNAGNI FVVSLAVADLVVAIYPYPLVLMSIFN-NGWNL---------------------------------------- ---------------------GYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYIC----HSLKY------- ----------DKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQY-DPRIYSCT------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------FAQSVSS AYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPD-RK------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------MSENGSFANCCEAGGWAVRPGWSGAGSARPSR-----TPRPPWVA PALSAVLIVTTAVDVVGNLLVILSVLRNR-KL----------------------------------RNAGNL FLVSLALADLVVAFYPYPLILVAIFY-DGWAL---------------------------------------- ---------------------GEEHCKASAFVMGLSVIGSVFNITAIAINRYCYIC----HSMAY------- ----------HRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEY-DPRIYSCT------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------FIQTAST QYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPE-SR------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------LCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVA INP-Q---------------------------------------EMAPQIPEGLFVTSYLLAYFNSCLNAIV YGLLN-------QNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQADAL---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|P50406|5HT6R_HUMAN/1-440 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------MVPEPGPTANSTPAWGAG-----PPSAPGGS GWVAAALCVVIALTAAANSLLIALICTQP-AL----------------------------------RNTSNF FLVSLFTSDLMVGLVVMPPAMLNALY-GRWVL---------------------------------------- ---------------------ARGLCLLWTAFDVMCCSASILNLCLISLDRYLLIL----SPLRY------- ----------KLRMTPLRALALVLGAWSLAALASFLPLLLGWHEL-GHARPPVPGQ---------------- ------------------------------------------------------------------------ -----------------------------------------------------------------CRLLASL PFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASL-TTGMASQASETLQVPRTPRPGVESADSRRLA- ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|Q01718|ACTHR_HUMAN/1-297 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------MKHIINSYENINNTAR-----NNSDCPRV VLPEEIFFTISIVGVLENLIVLLAVFKNK-NL----------------------------------QAPMYF FICSLAISDMLGSLYKILENILIILR-NMGYLKPRGSF---------------------------------- ---------------------ETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIF----HALRY------- ----------HSIVTMRRTVVVLTVIWTFCTGTGITMVIF-------------------------------- ------------------------------------------------------------------------ ---------------------------------------------------------------------SHH VPTVITFTSLFPLMLVFILCLYVHMFLLARSHTRKIST---------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|Q01726|MSHR_HUMAN/1-317 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------MAVQGSQRRLLGSLNSTPTAIPQLGLAANQ-----TGARCLEV SISDGLFLSLGLVSLVENALVVATIAKNR-NL----------------------------------HSPMYC FICCLALSDLLVSGSNVLETAVILLL-EAGALVARAAV---------------------------------- ---------------------LQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIF----YALRY------- ----------HSIVTLPRARRAVAAIWVASVVFSTLFIAY-------------------------------- ------------------------------------------------------------------------ ---------------------------------------------------------------------YDH VAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARL-HKRQR--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------MGPTLAVPTPYGCIGCKLPQ-----PEYPPALI IFMFCAMVITIVVDLIGNSMVILAVTKNK-KL----------------------------------RNSGNI FVVSLSVADMLVAIYPYPLMLHAMSI-GGWDL---------------------------------------- ---------------------SQLQCQMVGFITGLSVVGSIFNIVAIAINRYCYIC----HSLQY------- ----------ERIFSVRNTCIYLVITWIMTVLAVLPNMYIGTIEY-DPRTYTCI------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------FNYLNNP VFTVTIVCIHFVLPLLIVGFCYVRIWTKVLAARDPAGQN--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------PDNQLAEVRNFLTMFVIFLLFAVCWCPINVLTVLVA VSP-K---------------------------------------EMAGKIPNWLYLAAYFIAYFNSCLNAVI YGLLN-------ENFRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLARARAHARDQAREQDRAHACPAV EETPMNVRNVPLPGDAAAGHPDRASGHPKPHSRSSSAYRKSASTHHKSVFSHSKAASGHLKPVSGHSKPASG HPKSATVYPKPASVHFKADSVHFKGDSVHFKPDSVHFKPASSNPKPITGHHVSAGSHSKSAFSAATSHPKPT TGHIKPATSHAEPTTADYPKPATTSHPKPTAADNPELSASHCPEIPAIAHPVSDDSDLPESASSPAAGPTKP AASQLESDTIADLPDPTVVTTSTNDYHDVVVIDVEDDPDEMAV----------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|Q13639|5HT4R_HUMAN/1-388 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------MDKLDANVSSE-----EGFGSVEK VVLLTFLSTVILMAILGNLLVMVAVCWDR-QLR---------------------------------KIKTNY FIVSLAFADLLVSVLVMPFGAIELVQ-DIWIY---------------------------------------- ---------------------GEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAIC----CQPLVY------ ----------RNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNI-GIIDLIEKRKFNQNSNSTY------- ------------------------------------------------------------------------ -----------------------------------------------------------------CVFMVNK PYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQML-QRAGASSESRPQSADQHS-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------THRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDP FI--------------------------------------------DYTVPGQVWTAFLWLGYINSGLNPFL YAFLN-------KSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPA TSPLVAAQPSDT------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------MNSWD AGLAGLLVGTMGVSLLSNALVLLCLLHSA-DIR---------------------------------RQAPAL FTLNLTCGNLLCTVVNMPLTLAGVVA-QRQPA---------------------------------------- ---------------------GDRLCRLAAFLDTFLAANSMLSMAALSIDRWVAVV----FPLSY------- ----------RAKMRLRDAALMVAYTWLHALTFPAAALALSWLGF-HQLYASCTLCSRRP------------ ------------------------------------------------------------------------ -----------------------------------------------------------------DERLRFA VFTGAFHALSFLLSFVVLCCTYLKVLKVARFHCKRIDVI-TMQTLVLLVDLHPSVRERCL------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------EEQKRRRQRATKKISTFIGTFLVCFAPYVITRLVEL FS--------------------------------------------TVPIGSHWGVLSKCLAYSKAASDPFV YSLLR-------HQYRKSCKEILNRLLHRRSIHSSGLTGDSHSQNILPVSE--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHL-----ATEWNTVS KLVMGLGITVCIFIMLANLLVMVAIYVNR-RF----------------------------------HFPIYY LMANLAAADFFAGLAYFYLMFNTGPN-TRRL----------------------------------------- ---------------------TVSTWLLRQGLIDTSLTASVANLLAIAIERHITVF----RMQL-------- ----------HTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCIC-DIENCS-------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------NMAPLYS DSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRH-SSGP---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------RRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDV CC--------------------------------------------PQCDVLAYEKFFLLLAEFNSAMNPII YSYRD-------KEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSNDHSVV----------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|Q969N4|TAAR8_HUMAN/1-342 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------MTSNFSQPVVQLCYEDVNGSCIE-----TPYSPGSR VILYTAFSFGSLLAVFGNLLVMTSVLHFK-QL----------------------------------HSPTNF LIASLACADFLVGVTVMLFSMVRTVE-SCWYF---------------------------------------- ---------------------GAKFCTLHSCCDVAFCYSSVLHLCFICIDRYIVVT----DPLVY------- ----------ATKFTVSVSGICISVSWILPLTYSGAVFYTGVNDD-GLEELVSALNCVG------------- ------------------------------------------------------------------------ -----------------------------------------------------------------GCQIIVS QGWVLIDFLLFFIPTLVMIILYSKIFLIAKQQAIKIETT-SSKVESSSESYK-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------IRVAKRERKAAKTLGVTVLAFVISWLPYTVDILIDA FM--------------------------------------------GFLTPAYIYEICCWSAYYNSAMNPLI YALFY-------PWFRKAIKLILSGDVLKASSSTISLFLE-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|Q96P69|GPR78_HUMAN/1-363 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------MGPGE ALLAGLLVMVLAVALLSNALVLLCCAYSA-ELR---------------------------------TRASGV LLVNLSLGHLLLAALDMPFTLLGVMR-GRTPS---------------------------------------- ---------------------APGACQVIGFLDTFLASNAALSVAALSADQWLAVG----FPLRY------- ----------AGRLRPRYAGLLLGCAWGQSLAFSGAALGCSWLGY-SSAFASCSLRLPPE------------ ------------------------------------------------------------------------ -----------------------------------------------------------------PERPRFA AFTATLHAVGFVLPLAVLCLTSLQVHRVARRHCQRMDTV-TMKALALLADLHPSVRQRCL------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------IQQKRRRHRATRKIGIAIATFLICFAPYVMTRLAEL VP--------------------------------------------FVTVNAQWGILSKCLTYSKAVADPFT YSLLR-------RPFRQVLAGMVHRLLKRTPRPASTHDSSLDVAGMVHQLLKRTPRPASTHNGSVDTENDSC LQQTH------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|Q96RI8|TAAR6_HUMAN/1-345 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------MSSNSSLLVAVQLCYANVNGSCVK-----IPFSPGSR VILYIVFGFGAVLAVFGNLLVMISILHFK-QL----------------------------------HSPTNF LVASLACADFLVGVTVMPFSMVRTVE-SCWYF---------------------------------------- ---------------------GRSFCTFHTCCDVAFCYSSLFHLCFISIDRYIAVT----DPLVY------- ----------PTKFTVSVSGICISVSWILPLMYSGAVFYTGVYDD-GLEELSDALNCIG------------- ------------------------------------------------------------------------ -----------------------------------------------------------------GCQTVVN QNWVLTDFLSFFIPTFIMIILYGNIFLVARRQAKKIENT-GSKTESSSESYK-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------ARVARRERKAAKTLGVTVVAFMISWLPYSIDSLIDA FM--------------------------------------------GFITPACIYEICCWCAYYNSAMNPLI YALFY-------PWFRKAIKVIVTGQVLKNSSATMNLFSEHI------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|Q96RI9|TAAR9_HUMAN/1-348 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------MVNNFSQAEAVELCYKNVNESCIK-----TPYSPGPR SILYAVLGFGAVLAAFGNLLVMIAILHFK-QL----------------------------------HTPTNF LIASLACADFLVGVTVMPFSTVRSVE-SCWYF---------------------------------------- ---------------------GDSYCKFHTCFDTSFCFASLFHLCCISVDRYIAVT----DPLTY------- ----------PTKFTVSVSGICIVLSWFFSVTYSFSIFYTGANEE-GIEELVVALTCVG------------- ------------------------------------------------------------------------ -----------------------------------------------------------------GCQAPLN QNWVLLCFLLFFIPNVAMVFIYSKIFLVAKHQARKIEST-ASQAQSSSESYK-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------ERVAKRERKAAKTLGIAMAAFLVSWLPYLVDAVIDA YM--------------------------------------------NFITPPYVYEILVWCVYYNSAMNPLI YAFFY-------QWFGKAIKLIVSGKVLRTDSSTTNLFSEEVETD--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|Q96RJ0|TAAR1_HUMAN/1-339 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------MMPFCHNIINISCVK-----NNWSNDVR ASLYSLMVLIILTTLVGNLIVIVSISHFK-QL----------------------------------HTPTNW LIHSMATVDFLLGCLVMPYSMVRSAE-HCWYF---------------------------------------- ---------------------GEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVC----DPLRY------- ----------KAKMNILVICVMIFISWSVPAVFAFGMIFLELNFK-GAEEIYYKHVHCRGG----------- ------------------------------------------------------------------------ -----------------------------------------------------------------CSVFFSK ISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDA-NQKLQIGLEMKN-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------GISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDP FL--------------------------------------------HYIIPPTLNDVLIWFGYLNSTFNPMV YAFFY-------PWFRKALKMMLFGKIFQKDSSRCKLFLELSS----------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------MATALPPRLQPVRGNETLREHYQYVGKLAGR-----LKEASEGS TLTTVLFLVICSFIVLENLMVLIAIWKNN-KF----------------------------------HNRMYF FIGNLALCDLLAGIAYKVNILMSGKK-TFSL----------------------------------------- ---------------------SPTVWFLREGSMFVALGASTCSLLAIAIERHLTMI----KMRP-------- ----------YDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLH-NLPDCS-------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------TILPLYS KKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANH--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------NNSERSMALLRTVVIVVSVFIACWSPLFILFLIDV ACR------------------------------------------VQACPILFKAQWFIVLAVLNSAMNPVI YTLAS-------KEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAPSS CIMDKNAALQNGIFCN-------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|Q99679|GPR21_HUMAN/1-349 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------MNSTLDGNQSSHPFCLLAFG-----YLETVNFC LLEVLIIVFLTVLIISGNIIVIFVFHCAP-LLN---------------------------------HHTTSY FIQTMAYADLFVGVSCVVPSLSLLHH-PLPVE---------------------------------------- ---------------------ESLTCQIFGFVVSVLKSVSMASLACISIDRYIAIT----KPLTY------- ----------NTLVTPWRLRLCIFLIWLYSTLVFLPSFFHWGKPG-YHGDVFQWCA---------------- ------------------------------------------------------------------------ -----------------------------------------------------------------ESWHTDS YFTLFIVMMLYAPAALIVCFTYFNIFRICQQHTKDISER-QARFSSQSGETG-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------EVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLES S---------------------------------------------TGHSNRFASFLTTWLAISNSFCNCVI YSLSN-------SVFQRGLKRLSGAMCTSCASQTTANDPYTVRSKGPLNGCHI------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|Q9BZJ7|GPR62_HUMAN/1-368 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------MANSTG-----LNASEVAG SLGLILAAVVEVGALLGNGALLVVVLRTP-------------------------------------GLRDAL YLAHLCVVDLLAAASIMPLGLLAAPP-PGLGRVRL------------------------------------- ---------------------GPAPCRAARFLSAALLPACTLGVAALGLARYRLIV----HP---------- ----------LRPGSRPPPVLVLTAVWAAAGLLGALSLLGTPPAP-PPAPARCS------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------VLAGGLG PFRPLWALLAFALPALLLLGAYGGIFVVARRAALRPPRP-ARGSRLHSDSLDSRLSILPP------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------LRPRLPGGKAALAPALAVGQFAACWLPYGCACLAPA A------------------------------------------------RAAEAEAAVTWVAYSAFAAHPFL YGLLQ-------RPVRLALGRLSRRALPGPVRACTPQAWHPRALLQCLQRPPEGPAVGPSEAPEQTPELAGG RSPAYQGPPESSLS---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|Q9BZJ8|GPR61_HUMAN/1-451 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------MESSPIPQSSGNSSTLGRVPQTPGPSTASGVPEV-----GLRDVASE SVALFFMLLLDLTAVAGNAAVMAVIAKTP-------------------------------------ALRKFV FVFHLCLVDLLAALTLMPLAMLSSSA-LFDHALF-------------------------------------- ---------------------GEVACRLYLFLSVCFVSLAILSVSAINVERYYYVV----HPMRY------- ----------EVRMTLGLVASVLVGVWVKALAMASVPVLGRVSWE-EGAPSVPPGCSLQW------------ ------------------------------------------------------------------------ -----------------------------------------------------------------SHSAYCQ LFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAMQHGPL-PTWMETPRQRSESLSSRSTMVTSSGAPQTT-- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------PHRTFGGGKAAVVLLAVGGQFLLCWLPYFSFHLYVA LS-------------------------------------------AQPISTGQVESVVTWIGYFCFTSNPFF YGCLN-------RQIRGELSKQFVCFFKPAPEEELRLPSREGSIEENFLQFLQGTGCPSESWVSRPLPSPKQ EPPAVDFRIPGQIAEETSEFLEQQLTSDIIMSDSYLRPAASPRLES-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|Q9H1Y3|OPN3_HUMAN/1-402 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------MYSGNRSGGHGYWDGGGAAGAEGPAPAGTLSPA-----PLFSPGTY ERLALLLGSIGLLGVGNNLLVLVLYYKFQ-RL----------------------------------RTPTHL LLVNISLSDLLVSLFGVTFTFVSCLR-NGWVW---------------------------------------- ---------------------DTVGCVWDGFSGSLFGIVSIATLTVLAYERYIRVV----H----------- ----------ARVINFSWAWRAITYIWLYSLAWAGAPLLGWNRYI-LDVHGLGCTVDWK------------- ------------------------------------------------------------------------ -----------------------------------------------------------------SKDANDS SFVLFLFLGCLVVPLGVIAHCYGHILYSIRMLRCVEDLQ-TIQV---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------IKILKYEKKLAKMCFLMIFTFLVCWMPYIVICFLVV NG-------------------------------------------HGHLVTPTISIVSYLFAKSNTVYNPVI YVFMI-------RKFRRSLLQLLCLRLLRCQRPAKDLPAAGSEMQIRPIVMSQKDGDRPKKKVTFNSSSIIF IITSDESLSVDDSDKTNGSKVDVIQVRPL------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------MESGLLRPAPVSEVIVLHYNYTGKLRGA-----RYQPGAGL RADAVVCLAVCAFIVLENLAVLLVLGRHP-RF----------------------------------HAPMFL LLGSLTLSDLLAGAAYAANILLSGPL-TLKL----------------------------------------- ---------------------SPALWFAREGGVFVALTASVLSLLAIALERSLTMA----RRGP-------- ----------APVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLG-RLDACS-------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------TVLPLYA KAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPAR-PGTAGTTSTR---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------MPDTNST-----INLSLSTR VTLAFFMSLVAFAIMLGNALVILAFVVDK-NL----------------------------------RHRSSY FFLNLAISDFFVGVISIPLYIPHTLF-EWDF----------------------------------------- ---------------------GKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVS----NAVSYR------ ----------TQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWK-DEGSECE------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------PGFFSEW YILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQ-SHPGLTAVSSNICGHSFRGRLSSRRSLSASTE VPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQRE------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------MVIMGQCYYNETIGFFYNNSGKEL-----SSHWRPKD VVVVALGLTVSVLVLLTNLLVIAAIASNR-RF----------------------------------HQPIYY LLGNLAAADLFAGVAYLFLMFHTGPR-TARL----------------------------------------- ---------------------SLEGWFLRQGLLDTSLTASVATLLAIAVERHRSVM----AVQL-------- ----------HSRLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLC-ALDRCS-------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------RMAPLLS RSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMAEH-VSCH---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------MDLTYIPEDLSSCPKFVNKILSS-----HQPLFSCP GDNVFGYDWSHDYPLFGNLVIMVSISHFK-QL----------------------------------HSPTNF LILSMATTDFLLGFVIMPYSIMRSVE-SCWYF---------------------------------------- ---------------------GDGFCKFHTSFDMMLRLTSIFHLCSIAIDRFYAVC----YPLHY------- ----------TTKMTNSTIKQLLAFCWSVPALFSFGLVLSEADVS-GMQSYKILVACFNF------------ ------------------------------------------------------------------------ -----------------------------------------------------------------CALTFNK FWGTILFTTCFFTPGSIMVGIYGKIFIVSKQHARVISHV-PENTKGAVKK---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|Q9P1P5|TAAR2_HUMAN/1-351 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------MAVSSEQHELSHFKRTQTKKEKFNCSEYGNRSCPE-----NERSLGVR VAMYSFMAGSIFITIFGNLAMIISISYFK-QL----------------------------------HTPTNF LILSMAITDFLLGFTIMPYSMIRSVE-NCWYF---------------------------------------- ---------------------GLTFCKIYYSFDLMLSITSIFHLCSVAIDRFYAIC----YPLLY------- ----------STKITIPVIKRLLLLCWSVPGAFAFGVVFSEAYAD-GIEGYDILVACSSS------------ ------------------------------------------------------------------------ -----------------------------------------------------------------CPVMFNK LWGTTLFMAGFFTPGSMMVGIYGKIFAVSRKHAHAINNL-RENQ---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------NNQVKKDKKAAKTLGIVIGVFLLCWFPCFFTILLDP FL--------------------------------------------NFSTPVVLFDALTWFGYFNSTCNPLI YGFFY-------PWFRRALKYILLGKIFSSCFHNTILCMQKESE---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|Q9UBY5|LPAR3_HUMAN/1-353 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------MNECHYDKHMDFFYNRSNTDTV-----DDWTGTKL VIVLCVGTFFCLFIFFSNSLVIAAVIKNR-KF----------------------------------HFPFYY LLANLAAADFFAGIAYVFLMFNTGPV-SKTL----------------------------------------- ---------------------TVNRWFLRQGLLDSSLTASLTNLLVIAVERHMSIM----RMRV-------- ----------HSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLC-NISACS-------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------SLAPIYS RSYLVFWTVSNLMAFLIMVVVYLRIYVYVKRKTNVLSPH-TSGS---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------ISRRRTPMKLMKTVMTVLGAFVVCWTPGLVVLLLDG LN-------------------------------------------CRQCGVQHVKRWFLLLALLNSVVNPII YSYKD-------EDMYGTMKKMICCFSQENPERRPSRIPSTVLSRSDTGSQYIEDSISQGAVCNKSTS---- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|Q9UHM6|OPN4_HUMAN/1-478 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------MNP PSGPRVPPSPTQEPSCMATPAPPSWWDSSQSSISSLGRLPSISPTAPGTWAAAWVPLPT-----VDVPDHAH YTLGTVILLVGLTGMLGNLTVIYTFCRSR-SL----------------------------------RTPANM FIINLAVSDFLMSFTQAPVFFTSSLY-KQWLF---------------------------------------- ---------------------GETGCEFYAFCGALFGISSMITLTAIALDRYLVIT----RPLAT------- ----------FGVASKRRAAFVLLGVWLYALAWSLPPFFGWSAYV-PEGLLTSCSWDYM------------- ------------------------------------------------------------------------ -----------------------------------------------------------------SFTPAVR AYTMLLCCFVFFLPLLIIIYCYIFIFRAIRETGRALQTF-GACKGNGESLWQ-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------RQRLQSECKMAKIMLLVILLFVLSWAPYSAVALVAF AG-------------------------------------------YAHVLTPYMSSVPAVIAKASAIHNPII YAITH-------PKYRVAIAQHLPCLGVLLGVSRRHSRPYPSYRSTHRSTLTSHTSNLSWISIRRRQESLGS ESEVGWTHMEAAAVWGAAQQANGRSLYGQGLEDLEAKAPPRPQGHEAETPGKTKGLIPSQDPRM-------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|Q9Y2T5|GPR52_HUMAN/1-361 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------MNESRWTEWRILNMSSGIVNVSERHSCPLGFG-----HYSVVDVC IFETVVIVLLTFLIIAGNLTVIFVFHCAP-LLH---------------------------------HYTTSY FIQTMAYADLFVGVSCLVPTLSLLHY-STGVH---------------------------------------- ---------------------ESLTCQVFGYIISVLKSVSMACLACISVDRYLAIT----KPLSY------- ----------NQLVTPCRLRICIILIWIYSCLIFLPSFFGWGKPG-YHGDIFEWCA---------------- ------------------------------------------------------------------------ -----------------------------------------------------------------TSWLTSA YFTGFIVCLLYAPAAFVVCFTYFHIFKICRQHTKEINDR-RARFPSHEVDSSR------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------ETGHSPDRRYAMVLFRITSVFYMLWLPYIIYFLLES S---------------------------------------------RVLDNPTLSFLTTWLAISNSFCNCVI YSLSN-------SVFRLGLRRLSETMCTSCMCVKDQEAQEPKPRKRANSCSI-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|Q9Y5N1|HRH3_HUMAN/1-445 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------MERAPPDGPLNASGALAGEAAAAGGA-----RGFSAAWT AVLAALMALLIVATVLGNALVMLAFVADS-SL----------------------------------RTQNNF FLLNLAISDFLVGAFCIPLYVPYVLT-GRWTF---------------------------------------- ---------------------GRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVT----RAVSYR------ ----------AQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLS-GGSSIPEGHCY--------------- ------------------------------------------------------------------------ -----------------------------------------------------------------AEFFYNW YFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDG-AREAAGPEPPPEAQPSPPPPPGCWGCWQKGHG EAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKM VSQSFTQ----------------------------------------------------------------- ------------------------------------RFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRA AC-------------------------------------------HGHCVPDYWYETSFWLLWANSAVNPVL YPLCH-------HSFRRAFTKLLCPQKLKIQPHSSLEHCWK------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|O15354|GPR37_HUMAN/1-613 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------MRAPGALLARMSRLLLLLLLKVSASSALGVAPASRNETCLGESCAPTVI QRRGRDAWGPGNSARDVLRARAPREEQGAAFLAGPSWDLPAAPGRDPAAGRGAEASAAGPPGPPTRPPGPWR WKGARGQEPSETLGRGNPTALQLFLQISEEEEKGPRGAGISGRSQEQSVKTVPGASDLFYWPRRAGKLQGSH HKPLSKTANGLAGHEGWTIALPGRALAQNGSLGEGIHEPGGPRRGNSTNRRVRLKNPFY-----PLTQESYG AYAVMCLSVVIFGTGIIGNLAVMCIVCHN-YY----------------------------------MRSISN SLLANLAFWDFLIIFFCLPLVIFHEL-TKKWL---------------------------------------- ---------------------LEDFSCKIVPYIEVASLGVTTFTLCALCIDRFRAA----TNVQMY------ ----------YEMIENCSSTTAKLAVIWVGALLLALPEVVLRQLS-KEDLGFSGRAPAERCIIKISPDLPDT IY---------------------------------------------------------------------- -----------------------------------------------------------------VLALTYD SARLWWYFGCYFCLPTLFTITCSLVTARKIRKAEKACTR-G------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------NKRQIQLESQMNCTVVALTILYGFCIIPENICNIVT AYM-A---------------------------------------TGVSQQTMDLLNIISQFLLFFKSCVTPV LLFCL-------CKPFSRAFMECCCCCCEECIQKSSTVTSDDNDNEYTTELELSPFSTIRREMSTFASVGTH C----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|O43193|MTLR_HUMAN/1-412 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------MGSPWNGSDGPEGAREPPWPALPPCDERRC-----SPFPLGAL VPVTAVCLCLFVVGVSGNVVTVMLIGRYR-DM----------------------------------RTTTNL YLGSMAVSDLLILLGLPFDLYRLWRS-RPWVF---------------------------------------- ---------------------GPLLCRLSLYVGEGCTYATLLHMTALSVERYLAIC----RPLRA------- ----------RVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQ-DPGISVVPGLNGTARIASSPLASSPP LWLSRAPPPSPPSGPETAEAAALFSRECRPS----------------------------------------- -----------------------------------------------------------------PAQLGAL RVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGP-AA------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------SGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYI NTE-D---------------------------------------SRMMYFSQYFNIVALQLFYLSASINPIL YNLIS-------KKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|O43613|OX1R_HUMAN/1-425 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRD-----YLYPKQYE WVLIAAYVAVFVVALVGNTLVCLAVWRNH-HM----------------------------------RTVTNY FIVNLSLADVLVTAICLPASLLVDIT-ESWLF---------------------------------------- ---------------------GHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAIC----HPL--------- ----------LFKSTARRARGSILGIWAVSLAIMVPQAAVMECSS-VLPELANRTRLFSVCDERW------- ------------------------------------------------------------------------ -----------------------------------------------------------------ADDLYPK IYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTS-ALVRNWKRPSDQLGDLEQGLSGEPQPRARAFL AE---------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------VKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKR VFG-MFRQ------------------------------------ASDREAVYACFTFSHWLVYANSAANPII YNFLS-------GKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTT VLP--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|O43614|OX2R_HUMAN/1-444 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWRE-----YLHPKEYE WVLIAGYIIVFVVALIGNVLVCVAVWKNH-HM----------------------------------RTVTNY FIVNLSLADVLVTITCLPATLVVDIT-ETWFF---------------------------------------- ---------------------GQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAIC----HPL--------- ----------MFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECST-VFPGLANKTTLFTVCDERW------- ------------------------------------------------------------------------ -----------------------------------------------------------------GGEIYPK MYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSS-VVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAE ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------IKQIRARRKTARMLMIVLLVFAICYLPISILNVLKR VFG-MFAH------------------------------------TEDRETVYAWFTFSHWLVYANSAANPII YNFLS-------GKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTS ISTLPAANGAGPLQNW-------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|O60883|ETBR2_HUMAN/1-481 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------MRWLWPLAVSLAVILAVGLSRVSGGAPLHLGRHRAETQEQQSRSKRGTEDEEAKGVQQYVPEE WAEYPRPIHPAGLQPTKPLVATSPNPGKDGGTPDSGQELRGNLTGAPGQRLQIQNPLYP-----VTESSYSA YAIMLLALVVFAVGIVGNLSVMCIVWHSY-YL----------------------------------KSAWNS ILASLALWDFLVLFFCLPIVIFNEIT-KQRLL---------------------------------------- ---------------------GDVSCRAVPFMEVSSLGVTTFSLCALGIDRFHVAT----STLPKV------ ----------RPIERCQSILAKLAVIWVGSMTLAVPELLLWQLAQ-EPAPTMGTLDSCIMKPSASLPESLYS ------------------------------------------------------------------------ -----------------------------------------------------------------LVMTYQN ARMWWYFGCYFCLPILFTVTCQLVTWRVRGPPGRKSECR-A------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------SKHEQCESQLNSTVVGLTVVYAFCTLPENVCNIVVA YLS-T---------------------------------------ELTRQTLDLLGLINQFSTFFKGAITPVL LLCIC-------RPLGQAFLDCCCCCCCEECGGASEASAANGSDNKLKTEVSSSIYFHKPRESPPLLPLGTP C----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------- >sp|O95665|NTR2_HUMAN/1-410 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------