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18111 Nordhoff Street
Northridge, CA 91330-8303
Phone: (818) 677-3356
Fax: (818) 677-2034
Email:biology.dept@csun.edu
Office Location:
Chaparral Hall 5101
Hours:
Mon-Fri: 8:00am-5:00pm
Mary-Pat Stein
Associate Professor
Ph.D. University of New Mexico
M.S. Hood College
B.A. University of Pennsylvania
email: mary-patricia.stein@csun.edu
Phone: (818) 677-5603
Fax: (818) 677-2034
Office: Chaparral Hall 5420
Laboratory: Chaparral Hall 5435
Research/Laboratory Web Page: http://www.csun.edu/~ms440670
My research focuses on the molecular mechanisms of intracellular trafficking with particular emphasis on the ability of pathogens to alter normal cellular trafficking events to evade clearance by the host. Legionella pneumophila, the causative agent of Legionnaire’s disease, is a gram-negative bacterium that lives in fresh water amoeba and which can also invade human macrophages in the lung. L. pneumophila inhibits normal intracellular transport to lysosomes where the bacteria would be destroyed and then recruits host cell ER-derived vesicles to its vacuolar membrane. Both of these processes are dependent on the expression of a functional type IV secretion apparatus called the Dot/Icm system. This apparatus allows Legionella to inject bacterial effector proteins in the host cell cytosol. Remodeling of the L. pneumophila-containing vacuole creates an intracellular environment permissive for bacterial growth. My laboratory is currently working on identifying the L. pneumophila proteins responsible for the recruitment and fusion of host cell vesicles to the vacuolar membrane.
Representative Publications:
Cao, C., Laporte, J., Backer, J.M., Wandinger-Ness. A., and M.-P. Stein. 2007. Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes. Traffic, 8:1052-1067.
Stein, M.-P. and C.R. Roy. “Legionella and autophagy.” Autophagy in Immunity and Infection. Ed. Vojo Deretic. Wiley-VCH, 2005. 199-209.
Kagen, J.C., Stein, M.-P., Pypaert, M., and C.R. Roy. 2004. Legionella subvert the functions of Rab1 and Sec22b to create a replicative organelle. J. Exp. Med. 199:1201-1211.
Stein, M.-P., Dong, J., and A. Wandinger-Ness. 2003. Rab proteins and endocytic trafficking: potential targets for therapeutic intervention. Adv. Drug Delivery Rev. 55:1421-1437.
Stein, M.-P., Wandinger-Ness, A., and T. Roitbak. 2002. Altered trafficking and epithelial cell polarity in disease. Trends in Cell Biology, 12:374-381.