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Contact
18111 Nordhoff Street
Northridge, CA 91330-8303
Phone: (818) 677-3356
Fax: (818) 677-2034
Email:biology.dept@csun.edu
Office Location:
Eucalyptus Hall 2102
Hours:
Mon-Fri: 8:00am-5:00pm
Nancy H. Bishop
Professor
Ph.D. University of California, Los Angeles
email: nancy.bishop@csun.edu
Phone: (818) 677-2098
Fax: (818) 677-2034
Office: Magnolia Hall 4216
My research interest is mechanisms of immunity in syphilis, with emphasis on humoral immunity in experimental syphilis. Specific antitreponemal antibody develops during infection with Treponema pallidum, the causative agent of syphilis, and symptomatic infection is resolved, but the bacterial agent is not eliminated and symptoms may occur in humans. Antibody from an immune host has been shown to kill T. pallidum in vitro and to confer resistance to infection in the experimental model. Antibody does not eliminate the treponemes after infection and asymptomatic infection persists. My areas of investigation include the role of antibody in pathogenesis and immunity, protective function of antibody, me-chanism by which antibody kills T. pallidum, and immunocytochemistry and antigen location in treponemes by immunolectron microscopy with poly-valent and monoclonal antibodies.
A second research interest centers on the genetic and biochemical relationship between species of Mycobacterium and among strains of the M. avium- intracellulave complex isolated from clinical and environmental sources.
Additional Academic History:
Postdoctoral Scholar, University of California, Los Angeles, 1975-1977.
Clinical Laboratory Scientist (License OBZ 29), Specialist in Bacteriology and Serology, California State Department of Health Services, 1964.
Specialist Microbiologist, Public Health and Medical Laboratory Microbiology, National Registry of Microbiologists, American Academy of Microbiology, 1974.
Honor Societies: Phi Beta Kappa, Phi Kappa Phi, Sigma Xi, Omicron Delta Kappa.
Distinguished Professor Award, California State University, Northridge, 1982.
Founding Advisor, CSUN Microbiology Students Association, a Student Chapter of the American Society for Microbiology, 1983-2005.
President, Southern California Branch of American Society for Microbiology, 2003-2005.
Chair, Department of Biology, California State University, Northridge, 2002-2005.
Representative Publications:
Sebata, S., N. Glover, A. Holtzman, T. Aronson, S. Froman, and N. Bishop. 1995. Identification of mycobacteria found in potable water. Annu. Meet. Amer. Soc. Microbiol., 1995.
Woodward, S., C. Carlson, and N.H. Bishop. 1988. Elucidation by immunoelectron microscopy of the binding pattern of treponemacidal immunoglobulin G and complement to Treponema pallidum subsp. pallidum during killing by in vitro neutralization. Annu. Meet. Amer. Soc. Microbiol., 1988.
Lewinski, M.A. and N.H. Bishop. 1984. Demonstration of binding of specific polyclonal IgG to Treponema pallidum, Nichols strain, by immunoelectron microscopy. Ann. Meet. Amer. Soc. Microbiol., 1984.
Bishop, N.H. and J.N. Miller. 1983. Humoral immune mechanisms in acquired syphilis, in Pathogenesis and Immunology of Treponemal Infections, Ed. R.F. Schell and D.M. Musher. Marcel Dekker, Inc., New York.
Hanff, P.A., N.H. Bishop, J.N. Miller, and M.A. Lovett. 1983. Humoral immune response in experimental syphilis to polypeptides of Treponema pallidum. J. Immunol. 131: 1973-1977.
Pepose, J.S., N.H. Bishop, S. Feigenbaum, and J.N. Miller. 1980. The humoral immune response in rabbits infected with Treponema pallidum: Comparison of antibody levels measured by the staphylococcal protein A-IgG (SPA-TP) microassay with VDRL, FTA-ABS, and TPI antibody responses during the development of acquired resistance to challenge. Sex. Transm. Dis. 7: 125-129.
Zeltzer, P.M., J.S. Pepose, N.H. Bishop, and J.N. Miller. 1978. Microassay for immunoglobulin G antibodies to Treponema pallidum with radioiodinated protein A from Staphylococcus aureus: Immunoglobulin G response in experimental syphilis in rabbits. Infect. Immun. : 163-170.
Bishop, N.H. and J.N. Miller. 1976. Humoral immunity in experimental syphilis. I. The demonstration of resistance conferred by passive immunization. J. Immunol. 117: 191-196.
Bishop, N.H. and J.N. Miller. 1976. Humoral immunity in experimental syphilis. II. The relationship of neutralizing factors in immune serum to acquired resistance. J. Immunol. 117: 197-207.